Results 71 to 80 of about 6,222,733 (331)

Activating the Osteoblastic USP26 Pathway Alleviates Multi‐Organ Fibrosis by Decreasing Insulin Resistance

Advanced Science, EarlyView.
The loss of Ubiquitin Specific Peptidase 26 (USP26) in osteoblasts results in decreased bone formation, as well as multi‐organ fibrosis associated with insulin resistance (IR). Mechanistically, the absence of USP26 reduces glycolysis and lactate accumulation, leading to decreased histone H3 lysine 18 lactylation (H3K18LA) in the promoter region of KH ...
Jiyuan Tang, Wenkai Ye, Liang He, Zhou Dan, Leilei Chang, Zijie You, Yuanyue Jiang, Guoqing Tang, Lianfu Deng, Changwei Li   +9 more
wiley   +1 more source

Neuromodulatory control of localized dendritic spiking in critical period cortex. [PDF]

, 2019
Sensory experience in early postnatal life, during so-called critical periods, restructures neural circuitry to enhance information processing1. Why the cortex is susceptible to sensory instruction in early life and why this susceptibility wanes with age
Ringach, Dario L, Trachtenberg, Joshua T, Yaeger, Courtney E   +2 more
core  

Decadal-scale teleconnection between South Atlantic SST and southeast Australia surface air temperature in austral summer

Climate Dynamics, 2018
Austral summer (December–February) surface air temperature over southeast Australia (SEA) is found to be remotely influenced by sea surface temperature (SST) in the South Atlantic at decadal time scales.
Jiaqing Xue, Jianping Li, Cheng Sun, Sen Zhao, J. Mao, Di Dong, Yanjie Li, Juan Feng   +7 more
semanticscholar   +1 more source

GlycoChat Uncovers Glycan–Lectin Circuits in the Tumor Microenvironment of Pancreatic Cancer

Advanced Science, EarlyView.
Aberrant glycosylation drives cancer progression, yet its role in the tumor microenvironment remains unclear. We developed GlycoChat to map glycan–lectin circuits at single‐cell resolution. We discovered that cancer cells induce immunosuppressive macrophage differentiation and impair phagocytosis through interactions with CLEC10A and SIGLEC3 ...
Dinh Xuan Tuan Anh, Sunanda Keisham, Arun Burramsetty, Lalhaba Oinam, Koichiro Kumano, Akihiro Kuno, Osamu Shimomura, Tatsuya Oda, Hiroaki Tateno   +8 more
wiley   +1 more source

Tropical Cyclone-Induced Temperature Response in China’s Coastal Seas: Characteristics and Comparison with the Open Ocean

Journal of Marine Science and Engineering
Tropical cyclones (TCs) induce pronounced sea surface temperature (SST) cooling, which strongly influences their intensity. Accurate prediction of TC intensity is particularly important in coastal regions where landfall occurs. While SST cooling has been
Haixia Chen, Yuhao Liu, Qiyuzi Lu, Shoude Guan   +3 more
doaj   +1 more source

Post-error brain activity correlates with incidental memory for negative words [PDF]

, 2018
The present study had three main objectives. First, we aimed to evaluate whether short-duration affective states induced by negative and positive words can lead to increased error-monitoring activity relative to a neutral task condition.
Kroczek, Bartłomiej, Matyjek, Magdalena, Ociepka, Michał, Senderecka, Magdalena   +3 more
core   +3 more sources

Calcium Channel Blockers Inhibit Pancreatic Neuroendocrine Neoplasms Progression via Cav1.2‐Epigenetic Circuit

Advanced Science, EarlyView.
Our study reveals a novel mechanism of a positive regulatory circuit between Cav1.2 and H3K27ac for pancreatic neuroendocrine neoplasms (pNENs) progression. Cav1.2 is identified as a crucial target for promoting disease progression and correlates with malignant behaviors, which are remarkably inhibited by the administration of calcium channel blockers (
Yangyinhui Yu, Qiongcong Xu, Jinzhao Xie, Mingjian Ma, Xitai Huang, Yinhao Shi, Jiawei Zhou, Enliang Zhu, Ziyi Zhao, Ning Zhang, Zhide Liu, Jingyuan Ye, Xiaoyu Yin   +12 more
wiley   +1 more source

Enhancing assertive community treatment with cognitive behavioral social skills training for schizophrenia: study protocol for a randomized controlled trial. [PDF]

, 2015
BackgroundSchizophrenia leads to profound disability in everyday functioning (e.g., difficulty finding and maintaining employment, housing, and personal relationships).
Aarons, Gregory A, Granholm, Eric, Holden, Jason L, Mueser, Kim, Perivoliotis, Dimitri, Rufener, Christine, Sommerfeld, David   +6 more
core   +1 more source

Cytokine‐Engineered Chimeric Antigen Receptor‐T Cell Therapy: How to Balance the Efficacy and Toxicity

Advanced Science, EarlyView.
Cytokine‐engineered CAR‐T cells represent a promising immunotherapy against malignancies due to direct tumor killing and potent immunity response. However, significant toxicities, including CRS and ICANS, have restricted clinical applications. How to keep the risk‐benefit balance of the advanced therapy is of great importance for maximizing the benefit
Xinru Zhang, Gulizeba Aimaiti, Yuanye Guan, Yuzhe Sha, Wei Zhou, Jiefeng Shen, Bo Zhao, Wei‐En Yuan   +7 more
wiley   +1 more source