Results 81 to 90 of about 4,176 (185)

Health Research Funders and Justice: Obligations to Coordinate and Counterbalance

Bioethics, EarlyView.
ABSTRACT Government health research funders are frequently criticized on the grounds that their distribution of resources fails to reflect a population's disease burden. These critiques do not take into account what other research funders are doing. In this paper, I argue that this is a mistake.
Joseph Millum
wiley   +1 more source

Geochemical and granulometric fingerprints of 8200 years of westerly wind variability in inner‐fjord lake sediments from Svalbard

Boreas, EarlyView.
The Arctic is warming faster than any other region on Earth. As sea ice diminishes, the surface boundary conditions, such as roughness and air–sea coupling, change and open‐water fetch increases. This may enhance wind forcing on Arctic coasts. Lake sediments can record these changes through the deposition of wind‐blown grains and elements, offering ...
Zofia Stachowska, Willem G. M. van der Bilt, Jan Kavan, Mark F. A. Furze, Ingunn H. Thorseth, Mateusz C. Strzelecki   +5 more
wiley   +1 more source

Protective role of Galectin‐3 in prion disease through regulation of microglial PrPSc uptake

Brain Pathology, EarlyView.
Galectin‐3 (Gal3) is induced in reactive microglia during prion disease and promotes microglial uptake of PrPSc. Gal3 deficiency reduces prion sequestration and accelerates disease progression, revealing a protective role for Gal3. Abstract Microglia constitute a major innate defense mechanism against prion infection; however, the molecular pathways ...
Natallia Makarava, Tarek Safadi, Narayan P. Pandit, Olga Mychko, Olga Bocharova, Alexey Shevelkin, Kara Molesworth, Marta M. Lipinski, Ilia V. Baskakov   +8 more
wiley   +1 more source

Non‐canonical PKG1 regulation in cardiovascular health and disease

British Journal of Pharmacology, EarlyView.
It is well established that the cyclic GMP‐dependent protein kinase I (PKG1) is canonically activated by cyclic guanosine monophosphate (cGMP), enabling its regulation of vascular tone, cardiac function and smooth muscle homeostasis. However, diverse non‐canonical stimuli of PKG1 have also been identified.
Jie Su, Joseph Robert Burgoyne
wiley   +1 more source

Seizure Rates in Mild and Moderate Traumatic Brain Injury With Intracranial Hemorrhage: A Signal for Prospective Investigation of Seizure Prophylaxis in Moderate TBI. [PDF]

World J Surg
Cortez R, Weinberg J, Kupanoff K, Sullivan C, Snyder LA, McLaughlin D, Haller JT, Bonnin SS.   +7 more
europepmc   +1 more source

Neuronal and ion channel mechanisms of noxious heat sensing in mammals: A puzzle of sensory physiology and pharmacology

British Journal of Pharmacology, EarlyView.
Transient receptor potential vanilloid 1 (TRPV1) was the first noxious heat‐sensitive channel discovered. In rodents, its role is robust in the heat response of the cell body of polymodal nociceptors, but surprisingly small in that of the peripheral terminals in the skin.
Gábor Pethő, Peter W. Reeh
wiley   +1 more source

Cell-free tumour DNA in bronchoalveolar lavage: a proof of concept study. [PDF]

ERJ Open Res
Priel E, Zhang K, Xie Y, Halwagi L, Goffin J, Dvorkin Gheva A, Radadia N, Pertzov B, Mbuagbaw L, Brautigam Z, Radford K, Svenningsen S, Nair P, Paré G, Mukherjee M, Shargall Y.   +15 more
europepmc   +1 more source

Suicidal behavior and unsupervised hormone use in outpatient Brazilian transgender adolescents: health and psychosocial factors

Child and Adolescent Mental Health, EarlyView.
Background Transgender adolescents are at high risk for negative health outcomes resulting from marginalization and scarcity of services, intensified by the lack of epidemiological data addressing their needs. Understanding the sociodemographic, clinical, and behavioral characteristics of trans youths may support strategies to improve healthcare for ...
Saulo Vito Ciasca, Andrea Hercowitz, Gabriel Pardo Silveira, Leandro Augusto Pinto Benedito, Caio Antero Monteiro, Desiree Monteiro Cordeiro, Daniel Augusto Mori Gagliotti, Eduardo de Castro Humes, Alexandre Saadeh, Marco de Tubino Scanavino   +9 more
wiley   +1 more source

The collective application of shorebird tracking data to conservation

Conservation Biology, EarlyView.
Abstract Addressing urgent conservation issues, such as the drastic declines of North American migratory birds, requires creative, evidence‐based, efficient, and collaborative approaches. The abundance of over 50% of monitored North American shorebird populations has declined by over 50% since 1980. To address these declines, we developed a partnership
Autumn‐Lynn Harrison, Candace Stenzel, Alexandra Anderson, Jessica Howell, Richard B. Lanctot, Marley Aikens, Joaquín Aldabe, Liam A. Berigan, Joël Bêty, Erik Blomberg, Juliana Bosi de Almeida, Andy J. Boyce, David W. Bradley, Stephen Brown, Jay Carlisle, Edward Cheskey, Katherine Christie, Sylvain Christin, Rob Clay, Ashley Dayer, Jill L. Deppe, Willow English, Scott A. Flemming, Olivier Gilg, Christine Gilroy, Susan Heath, Jason M. Hill, J. Mark Hipfner, James A. Johnson, Luanne Johnson, Bart Kempenaers, Paul Knaga, Eunbi Kwon, Benjamin J. Lagassé, Jean‐François Lamarre, Christopher Latty, Don‐Jean Léandri‐Breton, Nicolas Lecomte, Pam Loring, Laura A. McDuffie, Rebecca McGuire, Scott Moorhead, Juan G. Navedo, David Newstead, Erica Nol, Alina Olalla‐Kerstupp, Bridget Olson, Elizabeth Olson, Julie Paquet, Allison K. Pierce, Jennie Rausch, Kevin Regan, Matthew E. Reiter, Amber M. Roth, Mike Russell, Daniel Ruthrauff, Sarah T. Saalfeld, Amy L. Scarpignato, Shiloh Schulte, Nathan R. Senner, Joseph A. M. Smith, Paul A. Smith, Zach Spector, Kelly Srigley Werner, Michelle L. Stantial, Audrey R. Taylor, T. Lee Tibbitts, Mihai Valcu, Nils Warnock, Walter Wehtje, Brad Winn, Michael B. Wunder   +71 more
wiley   +1 more source

Electroencephalographic Biomarkers of Deep Transcranial Magnetic Stimulation Treatment Response for Major Depressive Disorder in Older Adults: A Preliminary Study. [PDF]

Int J Geriatr Psychiatry
Prokop-Millar S, McIntyre-Wood C, Elsayed M, Schwartzmann B, Di Passa AM, Yaya H, Fein A, Vandehei E, Frey BN, Farzan F, MacKillop E, MacKillop J, Duarte D.   +12 more
europepmc   +1 more source