Results 151 to 160 of about 163,674 (312)

The Impact of Methotrexate on Cardiovascular Outcomes in Psoriasis: A Systematic Review and Meta‐Analysis

JEADV Clinical Practice, EarlyView.
ABSTRACT Background Psoriasis is a chronic immune‐mediated inflammatory disease with a global prevalence of 2%–3% and 1.3% in Brazil. It is associated with comorbidities such as obesity, hypertension, and diabetes, all of which contribute to increased cardiovascular risk due to systemic inflammation and endothelial dysfunction.
Tiago A. S. Costa, Sheila T. K. Medorima, Renata F. Magalhães   +2 more
wiley   +1 more source

Hypoxia‐Induced Histone Lactylation Promotes Ferroptosis in Cardiomyocytes via the Wnt/β‐Catenin Pathway

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT This study investigated the effects of histone lactylation on ferroptosis in hypoxia‐induced cardiomyocytes. A hypoxia model was established in AC16 cells treated with 2‐Deoxy‐D‐glucose (2‐DG, a glucose analogue), ferrostatin‐1 (Fer‐1, a selective ferroptosis inhibitor), lactate (LA), sh‐β‐catenin (shRNA of β‐catenin), or SKL2001 (an agonist ...
Xin‐Hua Zhu, Jing‐Wen Hou, Zhong‐Ying Lv, Ming‐Hui Sun, Xiao‐Yang Zhang, Lei Zhang, Mei Wang   +6 more
wiley   +1 more source

TET3‐Mediated m5C Modification of CCAT2 Accelerates Cardiac Microvascular Endothelial Cell Damage in Acute Coronary Syndrome

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Acute coronary syndrome (ACS) is a clinical syndrome involving myocardial ischemia. This study aimed to elucidate the mechanism of TET3 in ACS‐induced CMEC damage, thereby identifying a new target for ACS treatment. The expression of TET3 in ACS patients and healthy subjects was analyzed.
Jun‐Cheng Liu, Wen‐Juan Wang, Ting‐Ting Zhang, Qi‐Chong Yang, Haliminai Dilimulati, Song‐Tao An   +5 more
wiley   +1 more source

Simultaneous Intracranial and Spinal Hemorrhage Following Tenecteplase Thrombolysis for ST‐Elevation Myocardial Infarction: A Case Report [PDF]

Clin Case Rep
ABSTRACT Central nervous system (CNS) hemorrhage is a serious complication of intravenous thrombolysis. Tenecteplase, a fibrin‐specific thrombolytic agent, has a lower risk of hemorrhage than other agents. We report the first documented case of simultaneous intracranial and spinal hemorrhage following intravenous administration of tenecteplase.
Palliyaguru T, Ruwanpathirana P, Weeratunga P, Aravinthan M, Chang T.   +4 more
europepmc   +2 more sources

Deubiquitinase USP7 Regulates Neutrophil Extracellular Trap Formation and Inflammation in Lipopolysaccharide‐Treated Mice Through ICAM‐1 Expression

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Sepsis is typified by organ failure due to an unchecked host reaction to infection. This study aims to explore the mechanism of ubiquitin‐specific peptidase 7 (USP7) in sepsis with the involvement of intercellular adhesion molecule‐1 (ICAM‐1).
Hui Xu, Qi Wang, Jing‐Xian Fan, Yong‐Fu Xu, Jiao Yu   +4 more
wiley   +1 more source

Sex‐based differences in outcomes between male and female patients with bicuspid aortic stenosis following transcatheter aortic valve replacement: A meta‐analysis

Precision Medical Sciences, EarlyView.
Central illustration: Sex‐based differences in outcomes between male and female patients with bicuspid aortic stenosis following transcatheter aortic valve replacement. Abstract Bicuspid aortic valve (BAV) is a common congenital anomaly leading to early aortic stenosis.
Muhammad Huzaifa Ahmed Khan, Muneeb Khawar, Asad Ullah Farooq, Azooba Khalid, Syed Muhammad Ahsan, M. Hamza Naseer Awan, Muhammad Soban Nisar, Asim Elahi, Muhammad Aqib Faizan, Iqra Shahid, Abdullah Munir Ahmed, Faseeh Haider, Rejina Chhetri   +12 more
wiley   +1 more source

A new strategy of construction of porcine myocardial infarction model for preclinical research

VIEW, EarlyView.
This study proposes a strategy based on the anatomical classification of the porcine left coronary artery (LCA) to establish a stable and reproducible myocardial infarction (MI) model for preclinical research. A combination of LCA classification into nine types via angiography, screening of candidate subtypes, and application of a novel embolic ...
Shixing Huang, Haonan Zhang, Jie Jiang, Bei Qian, Yiming Zhong, Xinming Wang, Kai Wang, Jianglin Wang, Xuan Lu, Qiang Zhao, Xiaofeng Ye   +10 more
wiley   +1 more source

Global Emergency Medicine: A Scoping Review of the Literature From 2024

Academic Emergency Medicine, EarlyView.
ABSTRACT Objective The Global Emergency Medicine Literature Review (GEMLR) identifies impactful research in global emergency care. This 20th annual edition reviews GEM literature published in 2024 and highlights the growth of GEMLR over the years. Methods We conducted a scoping review of 2024 GEM articles through structured PubMed and gray literature ...
J. Austin Lee, Nana Serwaa A. Quao, Amanda Collier, Chris A. Rees, Morgan C. Broccoli, Nanaba A. Dawson‐Amoah, Vinay N. Kampalath, Joseph Ciano, Ashley Jacobson, Jennifer Jones, Joseph Leanza, Branden Skarpiak, Jonathan M. Strong, Braden J. Hexom, Global Emergency Medicine Literature Review (GEMLR) Group, Abdirahman Abdulle, Halley J. Alberts, Kimonia Bih Awanchiri, Emily Bartlett, Tal Berkowitz, Nidhi Bhaskar, Corey B. Bills, Joseph Bonney, Morgan C. Broccoli, Agatha Brzezinski, Whitney K. Bryant, Jonathan Chan, Joseph D. Ciano, Cassandra Clay, Ly Cloessner, Amanda Collier, Nanaba A. Dawson‐Amoah, Kamoga Dickson, Jonathan W. Dyal, Christian Engelen, Brandon Friedman, Stephanie Chow Garbern, Juliette Gerardo, Mindi Guptill, Reid Haflich, Alison S. Hayward, Braden J. Hexom, Taylor S. Hickey, Anneka Hooft, Emmanuel Oluyinka Idowu, Ashley A. Jacobson, Aqeel Jawahir, Jennifer E. Jones, Vinay N. Kampalath, Elizabeth M. Keating, Sean M. Kivlehan, Arthi S. Kozhumam, Colleen E. Laurence, Joseph Leanza, Samuel Lewis, J. Austin Lee, Gideon Loevinsohn, Parker Maddox, Mallika Manyapu, Michael Mathelier, Kevin J. Mercer, Rmaah Memon, Kevin Molyneux, Dana Naamani, Benjamin D. Nicholson, Hannah Ofosua Owusu, Gerard M. O’Reilly, Mayur Patel, Nana Serwaa Agyeman Quao, Sarah Rapaport, Chris A. Rees, Charlotte Roy, Megan M. Rybarczyk, Jessica Schmidt, Megan L. Schultz, Anand Selvam, Erin F. Shufflebarger, Yusra Shakil, Branden Skarpiak, Cheyenne Smith, Jonathan M. Strong, Janet Jebichii Sugut, Fadhila Tekka, W. Tyler Winders, Ann Wolski, Natalie Yabalwashi   +85 more
wiley   +1 more source

ST-elevation no myocardial infarction

Journal of Thrombosis and Thrombolysis, 2016
Damman, Peter, de Winter, Robbert J., Krucoff, Mitchell W.   +2 more
openaire   +3 more sources

Outcomes in Patients Requiring VENO‐Venous Extracorporeal Membrane Oxygenation After Cardiac Surgery: An Analysis From the PELS‐1 Study

Artificial Organs, EarlyView.
We report an insight from the PELS‐1– a multicentre, international registry focusing on postocardiotomy extracorporeal support use between 2000 and 2020. We focused on 24/2163 (1.1%) patients requiring V‐V ECMO after cardiac surgery. Mortality was high, with 21.7% of patients discharged alive and an overall 1‐year survival probability of 12.5 ...
Pasquale Nardelli, Silvia Mariani, Maria Elena De Piero, Bas C. T. van Bussel, Michele Di Mauro, Ann‐Kristin Schaefer, Diyar Saeed, Matteo Pozzi, Luca Botta, Udo Boeken, Robertas Samalavicius, Karl Bounader, Xiaotong Hou, Jeroen J. H. Bunge, Hergen Buscher, Leonardo Salazar, Bart Meyns, Michael A. Mazzeffi, Marco L. Sacha Matteucci, Sandro Sponga, Kollengode Ramanathan, Claudio Russo, Francesco Formica, Pranya Sakiyalak, Antonio Fiore, Daniele Camboni, Giuseppe Maria Raffa, Rodrigo Diaz, I‐wen Wang, Jae‐Seung Jung, Jan Belohlavek, Vin Pellegrino, Giacomo Bianchi, Matteo Pettinari, Alessandro Barbone, José P. Garcia, Kiran Shekar, Glenn Whitman, Roberto Lorusso, PELS Investigators   +39 more
wiley   +1 more source