Results 221 to 230 of about 163,674 (312)

Leucine‐Dependent SLC7A5–PGAM5 Interaction Promotes Advanced Atherosclerosis Through Hindering Mitochondrial Function of Macrophages

Advanced Science, Volume 13, Issue 7, 3 February 2026.
Higher plasma leucine is associated with increased risk of new‐onset myocardial infarction. Leucine deprivation alleviates advanced atherosclerosis in mice. Tumor‐induced leucine deprivation reprograms macrophage metabolism and increases CD5Lhi macrophages in mouse plaques. Mechanistically, leucine deficiency reduced SLC7A5‐PGAM5 binding in macrophages,
Shan Zhong, Xueyu Wang, Qingsong Li, Siqi Wang, Bin Sun, Wenjun Ni, Gengyu Zhou, Fan Wang, Xianwei Xie, Cheng Jin, Gang Xu, Peng Zhao, Xiang Peng, Feiyuan Han, Xiangwen Xi, Yidan Wang, Juan Xu, Yue Wang, Xia Gu, Shuo Li, Jian Zhang, Shuijie Li, Jinwei Tian   +22 more
wiley   +1 more source

The influence of midlife morbidity clusters on dementia risk: The ARIC study

Alzheimer's &Dementia, Volume 22, Issue 2, February 2026.
Abstract INTRODUCTION Understanding comorbidities’ combined impacts on dementia risk may offer a more comprehensive understanding of individuals’ risk. Using machine‐learning, we grouped individuals with similar midlife risk profiles into clusters and explored associations with dementia risk. METHODS Participants without dementia at baseline (1987–1989)
Elise Kinyanjui, Renee C. Groechel, Valerie Morrill, Keenan A. Walker, Anna M. Kucharska‐Newton, Thomas H. Mosley, Silvia Koton, David S. Knopman, Jordan Weiss, Rebecca F. Gottesman, Marco Egle   +10 more
wiley   +1 more source

Contemporary Management of ST-Elevation Myocardial Infarction-Related Cardiogenic Shock in New York: A Multicenter Registry. [PDF]

J Soc Cardiovasc Angiogr Interv
Adi A, Ramsis R, Rodriguez E, Miklin D, Jnani J, Lin A, Bali AD, Lebrun S, Kodra A, Griffin M, Pierce M, Alvarez Villela M.   +11 more
europepmc   +1 more source

When Myocarditis Masquerades as ST-Elevation Myocardial Infarction: A Case of Coxsackie B-induced Acute Heart Failure With Rapid Recovery. [PDF]

Cureus
Chaudhry A, Mangente A, Yildirim C, Alazzeh M, Ledley G.   +4 more
europepmc   +1 more source

CYP2C19 genotype testing for clopidogrel: A guideline developed by the UK Centre of Excellence in Regulatory Science and Innovation in Pharmacogenomics (CERSI‐PGx)

British Journal of Clinical Pharmacology, Volume 92, Issue 2, Page 329-347, February 2026.
Clopidogrel, an antiplatelet agent, is currently licensed in the United Kingdom for the prevention and treatment of atherothrombotic events in cerebrovascular disease, coronary artery disease and peripheral arterial disease. Clopidogrel requires metabolic activation by the cytochrome P450 enzyme CYP2C19 to be effective.
Cinzia Dello Russo, Iain Frater, Rebecca Kuruvilla, Stefanie Lip, Hannah O'Neill, Kerry Burke, Vicky Chaplin, Alexander S. F. Doney, Salim Elyas, Nicholas Greaves, Sophie Harding, David Hargroves, Judith Hayward, Dyfrig A. Hughes, Tom A. T. Hughes, Sree Kondapally, Patrick Mok, Aaron Peace, Imran Rafi, Simon Ray, Vicky Stinton, Luigi Venetucci, Munir Pirmohamed   +22 more
wiley   +1 more source

Bilateral 360-degree radial loops in a patient with inferior ST-elevation myocardial infarction. [PDF]

Postepy Kardiol Interwencyjnej
Theodoropoulos KC, Baltagianni E, Papadopoulos SF, Didagelos M, Kassimis G, Ziakas A.   +5 more
europepmc   +1 more source

Association of Sleep Disturbance With Survival After Colorectal Cancer Diagnosis: Results From the ColoCare Study

Cancer Medicine, Volume 15, Issue 2, February 2026.
ABSTRACT Introduction Sleep problems are common among cancer patients. The relationship between sleep disruption and clinical outcomes after colorectal cancer (CRC) diagnosis remains poorly understood. We investigated associations of sleep disruption with survival and recurrence in patients with CRC. Methods CRC patients with stages I–IV (N = 895) were
Anita R. Peoples, Victoria Damerell, Jennifer Ose, Erin M. Siegel, Tengda Lin, Sheetal Hardikar, Caroline Himbert, Mmadili N. Ilozumba, Petra Schrotz‐King, Sylvia L. Crowder, Adetunji T. Toriola, David Shibata, Christopher I. Li, Doratha A. Byrd, Elena S. Aßmann, Heather S. L. Jim, Jane C. Figueiredo, Cornelia M. Ulrich, Biljana Gigic   +18 more
wiley   +1 more source

ACEF score as a predictor of new-onset atrial fibrillation in patients with ST-elevation myocardial infarction: A retrospective cohort study. [PDF]

PLoS One
Akdeniz E, Hünük B, Yıldız C, Abdullahoğlu SD, Ortakaya M, Karabulut D, Turhan Çağlar FN, Kozan Ö.   +7 more
europepmc   +1 more source

OCT‐Guided Distal Left Main Bifurcation PCI: Mid‐Term Outcomes From a Multicenter South‐Asian Registry

Catheterization and Cardiovascular Interventions, Volume 107, Issue 2, Page 477-484, February 1, 2026.
ABSTRACT Background Optical coherence tomography (OCT)‐guided percutaneous coronary intervention (PCI) enhances treatment of complex coronary artery lesions, including left main (LM) disease, by enabling lesion morphology assessment and stent optimization, thereby reducing major adverse cardiac events (MACE).
Prathap Kumar, Shaneez Najmy, Manu Rajendran, Ali Shafeeq, Blessvin Jino   +4 more
wiley   +1 more source

The Uremic Toxin p-Cresyl Sulfate Is a New Predictor of Major Adverse Cardiovascular Events in Patients with ST-Elevation Myocardial Infarction. [PDF]

Toxins (Basel)
Raillon LA, Bochaton T, Glorieux G, Guebre-Egziabher F, Soulage CO.   +4 more
europepmc   +1 more source