Results 41 to 50 of about 4,205,258 (210)

The GBA1 p.E427K (p.E388K) Variant Is a Risk Factor for Synucleinopathies: A Meta‐Analysis

Movement Disorders, EarlyView.
Abstract Background Variants in GBA1 are important genetic risk factors for synucleinopathies, including Parkinson's disease (PD). Although several GBA1 variants are established risk or severity modifiers, the role of the p.E427K variant remains unclear.
Leah V. Chifamba, Sitki Cem Parlar, Emma N. Somerville, Lang Liu, Eric Yu, Farnaz Asayesh, Jamil Ahmad, Meron Teferra, Jennifer A. Ruskey, Cheryl Waters, Oury Monchi, Yves Dauvilliers, Nicolas Dupré, Alla Timofeeva, Anton Emelyanov, Sofya Pchelina, Irina Miliukhina, Lior Greenbaum, Sharon Hassin‐Baer, Orly Goldstein, Mandy Radefeldt, Peter Bauer, Christian Beetz, Allison A. Dilliott, James C. Beck, Konstantin Senkevich, ROPAD Study Group, The Parkinson's Foundation PD GENEration Study, Christine Klein, Roy N. Alcalay, Ziv Gan‐Or   +30 more
wiley   +1 more source

Prescribed pharmaceutical alternatives initiative coinciding with reductions in unregulated street opioid use among young people who use drugs: An interrupted time series analysis. [PDF]

Addiction
Abstract Background and aims In British Columbia, Canada, an initiative was implemented in 2020 to reduce overdose mortality by prescribing pharmaceutical opioids (primarily hydromorphone) as a substitute for the toxic unregulated drug supply. This study estimated changes in the level and trend of unregulated opioid use and non‐prescribed hydromorphone
McAdam E, Karamouzian M, Milloy MJ, Verdicchio C, Sayre EC, Hayashi K, Kerr T, DeBeck K.   +7 more
europepmc   +2 more sources

Evolutionary trade‐offs between beauvericin production and growth define divergent virulence strategies in Beauveria

Pest Management Science, EarlyView.
Two virulence strategies in Beauveria: a growth strategy characterized by rapid within‐host proliferation, and a toxin strategy involving antimicrobial activity and toxicity to insects Abstract BACKGROUND Pathogen virulence is often attributed to toxin production, yet toxins are metabolically costly and may not universally enhance fitness.
Shasha Hu, Lana L B de Carvalho, Ricardo A Polanczyk, Michael J Bidochka   +3 more
wiley   +1 more source

Butein Attenuates Cardiac Hypertrophy by Restoring Redox–Mitochondrial Homeostasis Through Nrf2–Sirt3 Signaling

Phytotherapy Research, EarlyView.
Butein attenuates pathological cardiac hypertrophy by activating Nrf2–Sirt3 signaling, restoring mitochondrial function and redox homeostasis. ABSTRACT Butein (3,4,2′,4′‐tetrahydroxychalcone) is a bioactive chalcone with antioxidant, anti‐inflammatory, and cytoprotective properties.
Tsendsuren Tungalag, Dong Kwon Yang
wiley   +1 more source

Local Eviction Moratoria and the Spread of COVID‐19

Southern Economic Journal, EarlyView.
ABSTRACT At different stages during the initial onset of the COVID‐19 pandemic, various US states and local municipalities enacted eviction moratoria. One of the main aims of these moratoria was to slow the spread of COVID‐19 infections. We deploy a semiparametric difference‐in‐differences approach with an event study specification to examine whether ...
Julia Hatamyar, Christopher F. Parmeter
wiley   +1 more source

The Churchwardens' accounts of St. Michael's in Bedwardine, Worcester, from 1539 to 1603 /

, 1896
Includes index.Spine title: St.
St. Michael's (Church : Bedwardine, England), Worcestershire Historical Society.   +1 more
core  

Differences in mammal community response to highway construction across different levels of human land use

Wildlife Biology, EarlyView.
Worldwide, transportation agencies have been involved in road mitigation efforts to reduce road mortality and promote connectivity of endangered species. Baseline data on how mammals respond to highway construction, however, are rarely collected in road mitigation and monitoring studies, including in the USA.
Thomas J. Yamashita, Jason V. Lombardi, Zachary M. Wardle, Michael E. Tewes, John H. Young   +4 more
wiley   +1 more source

How to stay wild in a highly domesticated landscape? Spatiotemporal behaviour of wolves in Germany

Wildlife Biology, EarlyView.
Wild animals can adapt to the increasing presence of humans by either becoming accustomed to it or by avoiding humans by spatiotemporal separation. The return of the wolf to the German lowlands raised the opportunity to study wolf behaviour in one of the most densely populated and fragmented countries in Europe, in an area where topography offers no ...
Ilka Reinhardt, Ugo Arbieu, Philipp Mendgen, Barbara Zimmermann, Anne Berger, Gesa Kluth, Thomas Mueller   +6 more
wiley   +1 more source

Facing Truths About Population Management

Zoo Biology, EarlyView.
Populations of wildlife, and domestic animals have large sinks for surplus animals. By contrast, zoos don't. Humans in industrialized societies are socialized with companion animals, i.e. surplus (i.e., typically denied reproduction) originating from unseen breeding cores.
Marcus Clauss, Andrew J. Abraham, Jörg Beckmann, Mads F. Bertelsen, Laurie Bingaman Lackey, Anita Burkevica, Miguel Casares, Severin Dressen, Adam Eyres, Karin Federer, Richard Gibson, Sven Hammer, Therese Hard, Stefan Hoby, Felix V. Husemann, Jacques Kaandorp, Christine M. Kaandorp‐Huber, Bjarne Klausen, Tobias Knauf‐Witzens, José Kok, Maya S. Kummrow, Sébastien Laurent, Arne Lawrenz, Sabrina Linn, Imke Lueders, Pascal Marty, Dennis W. H. Müller, Baptiste Mulot, Rolf‐Arne Ølberg, Theo B. Pagel, Zjef Pereboom, Jan Pluháček, Emile F. Prins, Sandra Reichler‐Danielowski, Douglas Richardson, Marco Roller, Lara Scherer, Tim F. Schikora, Chrispijn M. Schilp, Mark Snowball, Julia Stagegaard, Hanspeter W. Steinmetz, Job B. G. Stumpel, Cyriel Ververs, Chris Walzer, Christian Wenker, Guido Westhoff, Brian Zimmerman, João Pedro Meireles   +48 more
wiley   +1 more source

Earthquake scene, St. Michael's Church and Guard House

, 1886
oai:digital.library.musc.edu:cep/0An image of the earthquake damage to St. Michael's Church and the Guard House in Charleston, South Carolina. "Earthquake scene St. Michael Church and Guard House Charleston, S.C.," handwritten, appears in the lower right

core