Results 101 to 110 of about 37,362 (277)

Targeted Degradation of Picornaviral 3C Protease via PROTACs Confers High Barrier to Viral Resistance and Broad‐Spectrum Antiviral Activity

Advanced Science, EarlyView.
This study reports D34 as the first PROTAC degrader that targets the 3C protease of picornaviruses. D34 effectively degrades EV71 3C protease via the ubiquitin‐proteasome pathway. More importantly, D34 exhibits a high resistance barrier and shows broad‐spectrum antiviral activity against multiple picornaviruses, highlighting its potential as a novel ...
Weilong Deng, Junyu Chen, Yingyue Pang, Yuanyuan Zhang, Siqian Chen, Guoliang You, Xiaoman Tian, Zhongxin Xu, Jing Wang, Luqing Shang   +9 more
wiley   +1 more source

Transposable Element–Driven PIEZO Mutation Enhances Locust Flight in Plateau Hypoxia

Advanced Science, EarlyView.
Why transposable elements (TEs) persisted or expanded in genomes remains a mystery. Using integrated analysis of TE macro‐ and microevolution in locusts, our results showed that thousands of TE insertions promoted widespread adaptive variation. Subfamilies of candidate adaptive TEs amplified and reshaped species‐level genomic architecture.
Xuanzhao Li, Ying Liu, Longsheng Xing, Xianliang Huang, Yingming Sun, Lei Yue, Yuze Zhang, Huilong Du, Bing Chen   +8 more
wiley   +1 more source

Protection on needles sticks injuries of nurses in nursing work

Huli yanjiu, 2005
Needle stab wound have become one of the most common occupational hazards of nursing staff encountered in recent years.It can not only cause many blood transmitted diseases,but also lead to great psychological influence of nurses.Therefore,the protection
韩琳, 李继平
doaj  

Structural analysis of the stable form of fibroblast growth factor 2 – FGF2-STAB

Journal of Structural Biology: X
Fibroblast growth factor 2 (FGF2) is a signaling protein that plays a significant role in tissue development and repair. FGF2 binds to fibroblast growth factor receptors (FGFRs) alongside its co-factor heparin, which protects FGF2 from degradation.
Gabin de La Bourdonnaye, Martin Marek, Tereza Ghazalova, Jiri Damborsky, Petr Pachl, Jiri Brynda, Veronika Stepankova, Radka Chaloupkova   +7 more
doaj   +1 more source

Stab in the dark [PDF]

Medical Journal of Australia, 2011
openaire   +2 more sources

From Folding Mechanics to Robotic Function: A Unified Modeling Framework for Compliant Origami

Advanced Science, EarlyView.
A geometry‐consistent DDG framework captures compliant origami deformation from rigid‐like folding to soft panel bending. By tuning crease and panel stiffness, bistable snap‐through responses transform into smooth monostable deformation, enabling programmable stability and robot‐scale locomotion.
Bohan Zhang, Bo Wang, Huajiang Ouyang, Zhigang Wu, Haohao Bi, Jiawei Xu, Mingchao Liu, Weicheng Huang   +7 more
wiley   +1 more source

The strategy of storynomics and its application in teaching speaking for university students: A literature review

Diglosia
The main objective is to explore how integrating storytelling principles with strategic communication techniques can enhance oral language proficiency in higher education contexts.
Lery Prasetyo, Naniana Nimrod Benu, Ni Luh Supartini, Ni Made Ayu Sulasmini   +3 more
doaj   +1 more source

The Research Progress of Stab-Resistant Material

, 2011
The text summarizes raw material, manufacture method, stab-resistant mechanism, stab-resistant effect and the problem of the hard stab-resistant clothing, semi-soft Stab-resistant clothing and soft stab-proof clothing, and evaluates the advantages and ...
Shu Jie Zhang, Da Wei, Rui Wang
core   +1 more source

Cicada Wing‐Inspired Skeleton‐GO Networks in Melamine Foams for Multifunctional High‐Performance Composites

Advanced Science, EarlyView.
Inspired by the intricate microstructure of cicada wings, researchers developed a novel in situ skeleton‐graphene membrane architecture within lightweight foams. This bioinspired design dramatically enhances multifunctional performance: vibration attenuation time decreases by ∼83.3%, damping capacity increases by ∼179.3%, and compressive modulus rises ...
Jigang Feng, Anhao Li, Babak Safaei, Yun Kong, Yizhen Miao, Zhaoye Qin, Fulei Chu   +6 more
wiley   +1 more source

Patellofemoral stabilization with and without cartilage restoration

Journal of Cartilage & Joint Preservation
Introduction/Objectives: Cartilage restoration as an adjunct to patellofemoral (PF) soft tissue and/or bony stabilization in patients with symptomatic PF instability remains controversial.
Joseph M. Rund, John W. Welsh, M. Benjamin Burch, John R. Worley, Lasun O. Oladeji, Taylor Ray, Aaron D. Gray, Betina B. Hinckel, Seth L. Sherman   +8 more
doaj   +1 more source