Results 111 to 120 of about 294,593 (286)
Ingeniería e Investigación, 2009 This article describes the streamline upwind Petrov-Galerkin (SUPG) method as being a stabilisation technique for resolving the diffusion-advection-reaction equation by finite elements.
Carlos Humberto Galeano Urueña +2 more
doaj
Health Research in AfricaRÉSUMÉ La schizophrénie après avoir été stabilisée, peut laisser une symptomatologie résiduelle avec des signes variables selon les individus. Ainsi, certaines psychothérapies comme l’art-thérapie, peuvent se révéler nécessaire pour atténuer ces dits ...
Aka Rita Ahou +4 more
doaj +1 more source
Molecular Oncology, EarlyView.We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala +15 more
wiley +1 more source
Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity
Molecular Oncology, EarlyView.Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung +17 more
wiley +1 more source
Performance Study on Laterite Road Base Stabilised with Emulsions Incorporating Biochar
BuildingsThis study explores the utilisation of biochar as an innovative and sustainable additive to emulsions for stabilising laterite road base material in pavements, with the environmental benefit of sequestering atmospheric carbon and stable form storing.
Andrew Chilufya +3 more
doaj +1 more source
Molecular Oncology, EarlyView.Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee +8 more
wiley +1 more source
Molecular Oncology, EarlyView.Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat +8 more
wiley +1 more source
The role of Japanese local governments in stabilisation policy [PDF]
Local governments in Japan account for about 80 per cent of general government spending when excluding social security expenditures. Therefore, for the implementation of fiscal policy it is important how local governments will behave. On the basis of the
Pascha, Werner, Robaschik, Frank
core
Targeting p38α in cancer: challenges, opportunities, and emerging strategies
Molecular Oncology, EarlyView.p38α normally regulates cellular stress responses and homeostasis and suppresses malignant transformation. In cancer, however, p38α is co‐opted to drive context‐dependent proliferation and dissemination. p38α also supports key functions in cells of the tumor microenvironment, including fibroblasts, myeloid cells, and T lymphocytes.
Angel R. Nebreda
wiley +1 more source
Delayed Action and Uncertain Targets. How Much Will Climate Policy Cost? [PDF]
Despite the growing concern about actual on-going climate change, there is little consensus about the scale and timing of actions needed to stabilise the concentrations of greenhouse gases.
Alessandra Sgobbi +3 more
core +3 more sources