Results 131 to 140 of about 37,071 (265)

A randomized, observer-blind, phase 1 study of immune responses to three human adenovirus type 26 vector-based vaccines. [PDF]

EBioMedicine
Hertoghs N, Serroyen J, Tolboom J, van Heesbeen R, Ligtenberg N, Butler S, Merrall E, van Rosmalen M, Lavreys L, Maat-Ligthart M, McLean C, Luhn K, Hendriks J.   +12 more
europepmc   +1 more source

Hydrostatic pressure activates HIF‐1α via β‐catenin to promote stemness in breast cancer cells

FEBS Open Bio, EarlyView.
To mimic the elevated intestinal fluid pressure in breast cancers, we loaded human breast cancer cells (MCF‐7, MDA‐MB‐453, and BT‐474) to 50 mmHg hydrostatic pressure. Hydrostatic pressure exposure upregulated HIF‐1α and induced stemness in MCF‐7 and BT‐474 cells.
Da Zhai, Yong Xu, Jingjing Ma, Ratchanee Duangrat, Chen Yan, Jingyan Liang, Hua Wei, Bin Jiang, Tao‐Sheng Li   +8 more
wiley   +1 more source

Isolation and Reactivity of a Square-Planar Trisamido Silane. [PDF]

Angew Chem Int Ed Engl
Krengel DMJ, Wang X, Golz C, Herbst-Irmer R, Townrow OPE, Fischer M.   +5 more
europepmc   +1 more source

Stabilising Stabilisation / Marco Airaudo

, 2004
openaire   +2 more sources

The crystal structure of the Borrelia burgdorferi nicotinamidase BBE22 resolves a long‐standing annotation error

FEBS Open Bio, EarlyView.
The crystal structure of Borrelia burgdorferi nicotinamidase (PncA/BBE22) reveals the correct full‐length protein initiated from a non‐canonical AUU start codon. The structure validates previous biochemical findings and resolves a long‐standing annotation error, demonstrating that the truncated database sequence is structurally incompatible with the ...
Kalvis Brangulis
wiley   +1 more source

<i>Ab initio</i> insights into hydrogen-rich polynuclear non-metallic superalkali cations. [PDF]

Front Chem
Srivastava AK.
europepmc   +1 more source

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

Using inverse probability of censoring weighting to estimate hypothetical estimands in clinical trials: Should we implement stabilisation, and if so how? [PDF]

Stat Methods Med Res
Xuan J, Mt-Isa S, Latimer NR, Bell Gorrod H, Malbecq W, Vandormael K, Yorke-Edwards V, White IR.   +7 more
europepmc   +1 more source

Guiding AlphaFold to predict how Munc13‐1 opens Syntaxin‐1

FEBS Open Bio, EarlyView.
The syntaxin‐1 Habc‐domain (orange), linker (pink) and SNARE motif (yellow) form a closed conformation that binds to Munc18‐1 (violet) and is opened by the Munc13‐1 MUN domain (cyan) to form the SNARE complex that triggers neurotransmitter release.
Madhurima Chattopadhyay, Junjie Xu, Josep Rizo   +2 more
wiley   +1 more source

Why Luhmann? Social systems theory for a sociology of suicide in the platform age. [PDF]

Front Sociol
Fernández-Vilas E, Labora-González JJ, Coca JR.   +2 more
europepmc   +1 more source