Results 111 to 120 of about 55,649 (312)

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

open access: yesFEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens   +8 more
wiley   +1 more source

Electrostatically stabilised nanoparticles : Self-organization and electron-beam patterning

open access: yes, 2005
The self-organisation of citrate- and magnesium oleate-stabilised gold nanoparticles on SiO2/Si substrates was investigated. In drop deposition, nucleation of citrate-stabilised gold nanoparticles was observed at the rim of the droplet, symmetric or ...
Plaza, J.L.   +11 more
core   +1 more source

Synthesis of polyol based Ag/Pd nanocomposites for applications in catalysis

open access: yesResults in Physics, 2014
The synthesis of polyvinylpyrrolidone seed mediated Ag/Pd allied nanobimetallic particles was successfully carried out by the simultaneous reduction of the metal ions in ethylene glycol, diethylene glycol, glycerol, pentaerythritol and sodium borohydride
J.A. Adekoya   +5 more
doaj   +1 more source

Mixed‐class J‐domain protein scaffolds promote expanded aggregate handling and multivalent Hsp70 engagement during functional disaggregase assembly

open access: yesFEBS Letters, EarlyView.
Protein aggregates threaten proteostasis and cell health. In human cells, Hsp70–J‐domain protein‐based disaggregases remove aggregates, but how they assemble remains unclear. Our biochemical findings show that DNAJA2‐ and DNAJB1‐containing disaggregase scaffolds enhance luciferase aggregate targeting, and that Hsp70 recruitment by both J‐domain ...
Anna Szlachcic, Nadinath B. Nillegoda
wiley   +1 more source

Reconstructing enzyme evolution by protein engineering

open access: yesFEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler   +2 more
wiley   +1 more source

Foams and foam films stabilised by solid particles

open access: yes, 2008
Recent developments in the field of particle-stabilised aqueous foams and foam films are reviewed. Reports on ultrastable foams stabilised by solid particles are highlighted and factors responsible for the extraordinary foam stability are discussed in ...
Horozov, Tommy S.
core   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

open access: yesMolecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat   +8 more
wiley   +1 more source

Microstructural features of lime-stabilised pyroclastic soil

open access: yes, 2013
Some results of an experimental investigation on a lime-stabilised Italian pyroclastic soil are presented and discussed. This material is very reactive with calcium oxide (CaO) provided by the lime, the effectiveness of the stabilisation mainly depending
G. Russo, M. Cecconi, Russo, Giacomo
core   +1 more source

Editorial: Do Stabilisation Policies Stabilise? [PDF]

open access: yesIDS Bulletin, 1988
Christopher Colclough   +1 more
openaire   +1 more source

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

open access: yesMolecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge   +17 more
wiley   +1 more source

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