Results 171 to 180 of about 74,013 (296)

In silico and in vitro exploration of a tyrosinase for biocatalytic production of catechols

FEBS Open Bio, EarlyView.
Tyrosinase from Ralstonia pseudosolanacearum is a promising biocatalyst for producing valuable catechols from monophenol substrates. This tyrosinase is uniquely suited to this due to its high monophenolase : diphenolase ratio. We combined in silico docking and in vivo kinetic characterisation of this tyrosinase with 11 industrially relevant monophenols,
James Britton, Fang Zhao, Reeta Davis, Meg Walsh, Kevin E O'Connor, David O'Connell, Tanja Narancic   +6 more
wiley   +1 more source

Cumulative Metformin Use and Hepatocellular Carcinoma Risk After HCV SVR: A Multicentre Cohort Study. [PDF]

Liver Int
Calvo-Sánchez H, Jara-Fernández L, Encijo-Heredia R, Villarino I, Alvarado R, Quiñones-Calvo M, Gutiérrez ML, Miquel J, Torralba M, Catalá M, Gómez J, Albertos S, Barquero-Pérez Ó, Fernández-Rodríguez C, Larrubia JR.   +14 more
europepmc   +1 more source

Adenosine triphosphate as a modulator of protein interactions and stability

FEBS Open Bio, EarlyView.
ATP is best known as the cell's energy currency, but it also shapes how proteins fold, interact, aggregate and form biomolecular condensates. This review explains the emerging physical principles behind these effects, including weak binding to charged protein regions, magnesium‐dependent behaviour and concentration‐dependent control of protein ...
Shuyuan Tan, Robin Curtis
wiley   +1 more source

THE PROPERTIES OF LIGHTWEIGHT STABILISED BLOCKBOARD PANELS

Drewno, 2020
Rihards ROZIŅŠ, Jānis IEJAVS, Vilnis JAKOVĻEVS, Uldis SPULLE   +3 more
doaj   +1 more source

A PIEZO-Gated Mechanotransduction Timing Window Governs Scar Commitment in Wound Healing. [PDF]

Wound Repair Regen
Hamad RS, Ali MAM, Chaudhary AA, Elmorsy EA, Amer MM, Abdel-Hamed MR, El-Kott AF, Eltantawy W, AlShehri MA, Eissa H, Farrag AA, Saber S.   +11 more
europepmc   +1 more source

Dual native G‐quadruplex folding is associated with chromatin looping at the MYC locus

FEBS Open Bio, EarlyView.
BG4‐detectable G‐quadruplex (G4) in HaCaT and NHEK keratinocytes identified folded and unfolded G4s enriched at promoters/TSSs and active enhancers, whereas unfolded G4s also overlapped weak/poised enhancers. At MYC–PVT1, 3C‐qPCR detected enhancer–promoter looping only when G4s were simultaneously folded at both regulatory elements under native ...
Dieila Giomo de Lima, Gustavo Narvaes Guimarães, Emilyane de Oliveira Santana Amaral, Bianca Caroline Figueiredo Bianco, Manuel Jara‐Espejo, Sérgio Roberto Peres Line, Ana Paula de Souza, Aline Cristiane Planello   +7 more
wiley   +1 more source

GelMA‐based 3D spheroids recapitulate transcriptomic and functional hallmarks of myeloid sarcoma

FEBS Open Bio, EarlyView.
GelMA 5% hydrogels support the formation of myeloid leukemia spheroids that recapitulate MS‐specific features, including G1 arrest, apoptosis, and ECM‐driven transcriptomic reprogramming. The 3D model mimicked soft‐tissue‐like stiffness and oxygen conditions, and transcriptomic convergence with primary MS samples confirmed its utility as a preclinical ...
Nicolas Germain, Elise Buret, Le Hoang Thanh Nguyen, Marion Cocheteux, Nicolas Touya, Mélanie Dhayer, Romain Dubois, Frank Lafont, Sebastien Janel, Patrice Maboudou, Steve Lancel, Philippe Marchetti   +11 more
wiley   +1 more source

Antibiotic-Loaded Calcium Sulfate as an Adjunct in the Acute Management of a Traumatic Segmental First Metacarpal Defect. [PDF]

Cureus
Toro Aguilera Á, Grau Checa D, Fa Binefa M, Vila Lastra LJ.   +3 more
europepmc   +1 more source

Structural and biochemical insights into the thermostable esterase Ta0887 from Thermoplasma acidophilum

FEBS Open Bio, EarlyView.
In this study, a novel esterase from the thermoacidophilic archaeon Thermoplasma acidophilum was biochemically and structurally characterized. Our results demonstrate that Ta0887 is a highly thermostable esterase that preferentially hydrolyzes p‐nitrophenyl hexanoate and possesses an α‐helical cap domain that likely contributes to its substrate ...
Alejandro Delgado‐Rey, Miriam Livier Llamas‐García, Gabriela M. Montero‐Morán, Leticia Santos, Samuel Lara‐González   +4 more
wiley   +1 more source

Cow-dung stabilised compressed earth blocks: a mechanistic approach to understand its water resistance behaviour. [PDF]

Mater Struct
Kulshreshtha Y, Vardon PJ, Meesters GMH, van Loosdrecht MCM, Mota NJA, Jonkers HM.   +5 more
europepmc   +1 more source