Results 231 to 240 of about 8,523,362 (276)

Stable de novo protein design via joint conformational landscape and sequence optimization. [PDF]

Nat Commun
Cho Y, Dauparas J, Tsuboyama K, Rocklin GJ, Ovchinnikov S.   +4 more
europepmc   +1 more source

Targeting p38α in cancer: challenges, opportunities, and emerging strategies

Molecular Oncology, EarlyView.
p38α normally regulates cellular stress responses and homeostasis and suppresses malignant transformation. In cancer, however, p38α is co‐opted to drive context‐dependent proliferation and dissemination. p38α also supports key functions in cells of the tumor microenvironment, including fibroblasts, myeloid cells, and T lymphocytes.
Angel R. Nebreda
wiley   +1 more source

Impact of storage conditions on the stability and biological efficacy of trans-arachidin-1 and trans-arachidin-3. [PDF]

PLoS One
Khongrungjarat P, Tothong C, Pankaew C, Phimsen S, Khamto N, Kijchalao N, Wongkham W, Wongkham P, Chuaymaung W, Thonnondang A, Limmongkon A.   +10 more
europepmc   +1 more source

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

Molecular Oncology, EarlyView.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta, Yang Song, Madeleine Ndahayo, Anirudh Saxena, Theresa Guo, Dylan Z. Kelley, Jessica Gore, Andrew Hennigan, Alexa Anderson, John C. Papadimitriou, Daria A. Gaykalova   +10 more
wiley   +1 more source

Innovative Design of Aerostatic Bearings with Enhanced Dynamic Stability Inspired by the Laval Nozzle Principle. [PDF]

Nanomanuf Metrol
Chen X, Luo X, Xie W, Tian Y, Yang S.
europepmc   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Stability of non-canonical nucleic acid structure as a potential modulator of cell fate. [PDF]

Nucleic Acids Res
Takahashi S, Tateishi-Karimata H, Sugimoto N.   +2 more
europepmc   +1 more source

Parametric effects of turbulence on the flutter stability of suspension bridges

Niccolò Barni, Claudio Mannini
openalex   +1 more source

Evaluation of the color stability of three maxillofacial silicone materials after exposure to beverages: An in vitro study [PDF]

Anshul Chugh, Mariko Hattori, Cheewin Towithelertkul, Yuka I. Sumita, Noriyuki Wakabayashi   +4 more
openalex   +1 more source

Cotargeting TREM2 and IL2 pathways triggers multipronged anticancer immunity

Molecular Oncology, EarlyView.
Von Locquenghien et al. report that MiTE‐144, a triggering receptor expressed on myeloid cells 2 (TREM2) blocking antibody fused to interleukin‐2 (IL2) variant with tumour microenvironment restricted activation, demonstrates superior anticancer efficiency in a preclinical setting.
Isaure Vanmeerbeek, Jenny Sprooten, Abhishek D. Garg   +2 more
wiley   +1 more source