Results 191 to 200 of about 25,800,498 (305)

Intrapatient tumour heterogeneity and clonal evolution in an autopsy study of metastatic salivary gland cancer

Molecular Oncology, EarlyView.
Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche, Niels J. van Ruitenbeek, Charlotte Adang, Luke O'Gorman, Pui Yuen Lee, Willemijn M. Klein, Adriana C. H. van Engen‐van Grunsven, Jack A. Schalken, Sander Bervoets, Gerald W. Verhaegh, Carla M. L. van Herpen   +10 more
wiley   +1 more source

Frequency-domain stability analysis of mixed traffic flow considering communication degradation and human driving heterogeneity. [PDF]

PLoS One
Han H, Li F, Hao Z, Qi L, Wei Z, Zhao C.
europepmc   +1 more source

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

Molecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi, Tuan Khang Huynh, Adway Kadam, Zahra Kardan, Yue Yan, Amina Jamal Laham, Sampath Kumar Loganathan   +6 more
wiley   +1 more source

Geschlecht und Macht in der Türkei : Feminismus, Islam und die Stärkung der türkischen Demokratie / European Stability Initiative

, 2007
unknown
core   +1 more source

Spatial Stability Analysis of Curved Shallow Mixing Layers

Spatial stability analysis of slightly curved shallow mixing layers is presented in the paper. Linear stability problem is solved by means of the collocation method based on Chebyshev polynomials.
Eglīte, Irina, Koliškins, Andrejs
core  

A fractional SEIVRB model for aquatic diseases dynamics with stability analysis and numerical solution. [PDF]

Sci Rep
Kosari S, Heydari MH, Sattari M, Bayram M.   +3 more
europepmc   +1 more source

Castration‐resistant prostate cancer cells are addicted to the high activity of cyclin‐dependent kinase 2

Molecular Oncology, EarlyView.
We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee, Alessia Marin, Shivani Yalala, Harri M. Itkonen   +3 more
wiley   +1 more source

Linear Stability Analysis of Mixing Layers in Two-Phase Shallow Flows

Linear stability analysis of mixing layers in two-phase shallow flows is performed in the present paper. Hyperbolic tangent base flow velocity profile is used to model shallow mixing layer of two merging streams.
Koliškina, Valentīna, Volodko, Inta
core  

Numerical robustness of COVID-19 model with Lyapunov stability analysis. [PDF]

Sci Rep
Pandey A, Ghosh S.
europepmc   +1 more source

Partial FAK suppression promotes tumor growth, an effect reversed by macrophage p110δ PI3K inactivation

Molecular Oncology, EarlyView.
Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou, Niki Tzenaki, Anna Tsapara, Maria Tzardi, Evangelia A. Papakonstanti   +4 more
wiley   +1 more source