Results 161 to 170 of about 7,224,432 (309)

Castration‐resistant prostate cancer cells are addicted to the high activity of cyclin‐dependent kinase 2

Molecular Oncology, EarlyView.
We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee, Alessia Marin, Shivani Yalala, Harri M. Itkonen   +3 more
wiley   +1 more source

Integrated slope stability assessment of earthen canals under seismic loading using pseudostatic analysis and vetiver grass reinforcement. [PDF]

Sci Rep
Hazim W, Ziar A.
europepmc   +1 more source

Turkey's dark side : party closures, conspiracies and the future of democracy / European Stability Initiative

, 2008
unknown
core   +1 more source

Peer assessment assisted by technology

, 2012
A common theme from the National Student Survey is that students want more feedback, but increasing the amount of teacher-student feedback is not practicable. Peer assessment, if carefully supported, can be a cost-effective solution.
Barr, Niall, Hamer, John, Brown, C., Hamer, J., Honeychurch, Sarah, Brown, Craig, Honeychurch, S., Barr, N.   +7 more
core  

Partial FAK suppression promotes tumor growth, an effect reversed by macrophage p110δ PI3K inactivation

Molecular Oncology, EarlyView.
Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou, Niki Tzenaki, Anna Tsapara, Maria Tzardi, Evangelia A. Papakonstanti   +4 more
wiley   +1 more source

Probabilistic slope stability assessment of variably saturated overburden dump slopes. [PDF]

Sci Rep
Kumar A, Anand A, Singh RV, Hasnain SMM, Agrawal R, Maurya P, Kumar R.   +6 more
europepmc   +1 more source

The great debate : Germany, Turkey and the Turks : part I: intellectuals / European Stability Initiative

, 2010
unknown
core   +1 more source

Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer

Molecular Oncology, EarlyView.
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim, Maryam Aslam, Elouise Torruella, Alphons Sony, Asif Rahman, Simira Smith, Columba de la Parra, Moira Sauane   +7 more
wiley   +1 more source

An interpretable Hallmark pathway activity classifier for distinguishing CIN3/HSIL from invasive cervical squamous carcinoma: Development, external validation, and feature stability assessment. [PDF]

PLoS One
Jia M, Song Y, Shang J, Zhuang L, Xie S, Cao N, Ye S, Zhuo Y, Ye M.   +8 more
europepmc   +1 more source

Microsatellite Stability Assessment [PDF]

, 2020
openaire   +1 more source