Results 91 to 100 of about 1,403,536 (292)

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

2D calculation method on global stability safety factor of diaphragm wall slurry trench based on minimum potential energy principle

AIP Advances
In order to limit the phenomenon that the global stability safety factor (GSF) of the diaphragm wall slurry trench calculated by the two-dimensional (2D) wedge method is too small, the 2D calculation model on global instability of trench wall is ...
Lin Wang, Guojian Shao, Yuebo Fan, Jingbo Su, Yang Sun, Dawei Guan, Sen Yao, Chunyu Li   +7 more
doaj   +1 more source

Three-dimensional stability calculation method for high and large composite slopes formed by mining stope and inner dump in adjacent open pits

International Journal of Mining Science and Technology
The 2D limit equilibrium method is widely used for slope stability analysis. However, with the advancement of dump engineering, composite slopes often exhibit significant 3D mechanical effects.
Zuchao Liang, Dong Wang, Guanghe Li, Guangyu Sun, Mingyu Yu, Dong Xia, Chunjian Ding   +6 more
doaj   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Resonance bifurcations from robust homoclinic cycles

, 2009
We present two calculations for a class of robust homoclinic cycles with symmetry Z_n x Z_2^n, for which the sufficient conditions for asymptotic stability given by Krupa and Melbourne are not optimal.
Aguiar M Ashwin P Dias A Field M, Chossat P, Claire M Postlethwaite, Field M, Field M, Hofbauer J, Hofbauer J, Jonathan H P Dawes, Krupa M, Melbourne I, Whittaker E T   +10 more
core   +2 more sources

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Stability Study of Confined Aquifer Foundation Pit Bottom Plate Inrush Based on Nonlinear Failure Criterion

Chengshi guidao jiaotong yanjiu
[Objective] In water-rich rock stratum regions, preventing confined aquifer inrush accidents is a key focus and challenge in the design and construction of deep foundation pit projects.
Xiao YU, Qinxing LI, Chi LIU, Hongtao WANG, Huajun ZHANG, Zhaoteng XUAN, Jianhua LI   +6 more
doaj   +1 more source

Two-electron atoms, ions and molecules

, 2009
The quantum mechanics of two-electron systems is reviewed, starting with the ground state of the helium atom and helium-like ions, with central charge $Z\ge 2$.
Griffiths David J., Hallstein Høgaasen, Jean-Marc Richard, Kroemer Herbert, Lide D. R., Mandl Franz, Park David, Paul Sorba, Peebles P. J. E., Suzuki Y., Wold E.   +10 more
core   +3 more sources

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source