Results 61 to 70 of about 1,403,536 (292)

Health‐Related Quality of Life and Symptom Severity Among Patients With PIK3CA‐Related Overgrowth Spectrum: A Mixed‐Methods Study to Understand Real‐World Experience With Alpelisib Treatment

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background PIK3CA‐related overgrowth spectrum (PROS) includes several rare overgrowth disorders resulting from somatic gain‐of‐function mutations in PIK3CA. Despite treatment advances, including the recent approval of alpelisib for PROS in the United States, literature detailing the patient experience with PROS is limited.
Vamsi Bollu, Kaitlin LaGasse, Cory D. Saucier, Kimberly Raymond, Miranda Lauher‐Charest, Lauren Crowder, Beilei Cai, Mary Lisha Paul, Denise Adams   +8 more
wiley   +1 more source

Marginal stability in jammed packings: quasicontacts and weak contacts

, 2014
Maximally random jammed (MRJ) sphere packing is a prototypical example of a system naturally poised at the margin between underconstraint and overconstraint. This marginal stability has traditionally been understood in terms of isostaticity, the equality
Kallus, Yoav, Torquato, Salvatore
core   +1 more source

Two Faces of NOTCH1 in Childhood Lymphoblastic T‐Cell Neoplasia: Prognostic Divergence of Mutational and Structural Aberrations

Pediatric Blood &Cancer, EarlyView.
ABSTRACT In pediatric patients, T‐cell lymphoblastic lymphoma (T‐LBL) survival exceeds 80%. Relapse remains associated with limited curative options. Frontline treatment is largely extrapolated from T‐cell acute lymphoblastic leukemia (T‐ALL) treatment, reflecting the ongoing debate, whether both entities represent distinct diseases or variants within ...
Marie C. Heider, Amelie Alfert, Marc Hotfilder, Birgit Burkardt, Marcel te Vrugt   +4 more
wiley   +1 more source

Color Reflection Invariance and Monopole Condensation in QCD [PDF]

, 2003
We review the quantum instability of the Savvidy-Nielsen-Olesen (SNO) vacuum of the one-loop effective action of SU(2) QCD, and point out a critical defect in the calculation of the functional determinant of the gluon loop in the SNO effective action. We
A. Belavin, A. Kronfeld, A. Polyakov, A. Yildiz, B. De Witt, B. De Witt, C. Flory, C. Rajiadakos, D. G. Pak, D. Gross, E. Langman, G. Bali, G. K. Savvidy, G. ’t Hooft, G. ’t Hooft, H. Gies, H. Politzer, H. Shiba, H. Suganuma, J. Honerkamp, J. Schwinger, J. Stack, K. Kondo, K. Kondo, L. Faddeev, L. Faddeev, L. Fadeev, M. Claudson, M. Reuter, N. K. Nielsen, R. Battyr, S. K. Blau, S. Mandelstam, S. Shabanov, S. Shabanov, T. Suzuki, T. Suzuki, T. T. Wu, V. Schanbacher, W. Dittrich, W. S. Bae, W. S. Bae, Y. M. Cho, Y. M. Cho, Y. M. Cho, Y. M. Cho, Y. M. Cho, Y. M. Cho, Y. M. Cho, Y. M. Cho, Y. M. Cho, Y. M. Cho, Y. M. Cho, Y. M. Cho, Y. M. Cho, Y. M. Cho, Y. Nambu, Z. Ezawa   +57 more
core   +2 more sources

Clinical and Biological Features of Response in Resistant Neuroblastoma to 131I‐Metaiodobenzylguanidine Radiotherapy in the Anti‐GD2 Immunotherapy Era

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background 131I‐metaiodobenzylguanidine (131I‐MIBG) radiotherapy is a key treatment for relapsed and refractory (R/R) neuroblastoma (NB). Patients with R/R disease treated in the modern era are increasingly exposed to anti‐GD2 immunotherapy, which exerts selective pressure and may modify both tumor cell state and microenvironment.
Benjamin J. Lerman, Katherine K. Matthay, Fabienne Hollinger, Catriona Black, Ann A. Lazar, Miguel Pampaloni, Steven G. DuBois, Kieuhoa T. Vo   +7 more
wiley   +1 more source

Effects of the Fluid Replacement Method During Online Hemodiafiltration on the Solute Removal Performance and Biocompatibility Using the Asymmetric Cellulose Triacetate Membrane

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Introduction Pre‐dilution online hemodiafiltration (Pre‐HDF) is predominantly used in Japan, whereas post‐dilution online HDF (Post‐HDF) is more common in Europe. An asymmetric cellulose triacetate (ATA) membrane may improve biocompatibility.
Kenji Sakurai, Yoshitaka Kurihara, Fumi Yamauchi, Hiromi Hosoya, Takeshi Saito   +4 more
wiley   +1 more source

Revealing the structure of land plant photosystem II: the journey from negative‐stain EM to cryo‐EM

FEBS Letters, EarlyView.
Advances in cryo‐EM have revealed the detailed structure of Photosystem II, a key protein complex driving photosynthesis. This review traces the journey from early low‐resolution images to high‐resolution models, highlighting how these discoveries deepen our understanding of light harvesting and energy conversion in plants.
Roman Kouřil
wiley   +1 more source

Improvement of the Thermal Stability and Aqueous Solubility of Three Matrine Salts Assembled by the Similar Structure Salt Formers

Pharmaceuticals
Matrine (MAT), a natural Chinese herbal medicine, has a unique advantage in the treatment of various chronic diseases. However, its low melting point, low bioavailability, and high dosage restrict its subsequent development into new drugs. In this study,
Yeyang Wang, Baoxi Zhang, Wenwen Wang, Penghui Yuan, Kun Hu, Li Zhang, Dezhi Yang, Yang Lu, Guanhua Du   +8 more
doaj   +1 more source

Stability Analysis of Milling Process with Multiple Delays

Applied Sciences, 2020
Cutting chatter is extremely harmful to the machining process, and it is of great significance to eliminate chatter through analyzing the stability of the machining process.
Yonggang Mei, Rong Mo, Huibin Sun, Bingbing He, Kun Bu   +4 more
doaj   +1 more source

Stability Analysis of the Chiral Transition in SU(4) Gauge Theory with Fermions in Multiple Representations

, 2017
We present a Pisarski-Wilczek stability analysis of SU(4) gauge theory coupled simultaneously to fermions charged under the fundamental and two-index antisymmetric representations of the gauge group.
Hackett, Daniel C.
core   +1 more source