Results 141 to 150 of about 12,637,990 (355)

PYCR1 inhibition in bone marrow stromal cells enhances bortezomib sensitivity in multiple myeloma cells by altering their metabolism

Molecular Oncology, EarlyView.
This study investigated how PYCR1 inhibition in bone marrow stromal cells (BMSCs) indirectly affects multiple myeloma (MM) cell metabolism and viability. Culturing MM cells in conditioned medium from PYCR1‐silenced BMSCs impaired oxidative phosphorylation and increased sensitivity to bortezomib.
Inge Oudaert, Lauren van den Broecke, Osman Aksoy, Judith Lind, Sonia Vallet, Arne Van der Vreken, Gamze Ates, Ann Massie, Ken Maes, Kim De Veirman, Elke De Bruyne, Karin Vanderkerken, Klaus Podar, Eline Menu   +13 more
wiley   +1 more source

Research progress on period of validity and storage conditions of opened insulin

Huli yanjiu, 2015
AbstractIt summarized the research progress on the period of validity of insulin after opening from 4 aspects including standard made by the factory,chemical stability,biological stability and storage conditions.It put forward that the period of ...
赵小磊, 郑思琳
doaj  

MANAGEMENT OF ECONOMIC STABILITY IN CONDITIONS OF GLOBALIZATION

Економіка та суспільство
The relevance of this research is because globalization is rapidly changing the economic environment of enterprises, in particular, forming new challenges in modern management practices, such as increasing competition in global markets, the need to ...
Михайло Тарасюк, Тетяна Кулініч, Світлана Микуланинець   +2 more
doaj   +1 more source

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

Generalized stability conditions for coupled neural networks with delay feedbacks. [PDF]

Heliyon, 2019
Maisnam S, Brojen Singh RK.
europepmc   +1 more source

Mitochondrial Protein Lipoylation and the 2-Oxoglutarate Dehydrogenase Complex Controls HIF1α Stability in Aerobic Conditions [PDF]

, 2016
Stephen P. Burr, Ana S.H. Costa, Guinevere L. Grice, Richard T. Timms, Ian Lobb, Peter Freisinger, Roger B. Dodd, Gordon Dougan, Paul J. Lehner, Christian Frezza, James A. Nathan   +10 more
openalex   +1 more source

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

The Stability Conditions of the Pump Structure Vibration

Al-Khawarizmi Engineering Journal, 2012
The general approach of this research is to assume that the small nonlinearity can be separated from the linear part of the equation of motion. The effect of the dynamic fluid force on the pump structure system is considered vibrates at its natural ...
Nassir Hassan Abdul Hussain Al Hariri
doaj   +2 more sources

Characteristics of Solar Panel Stability Under Operating Conditions

Doklady Belorusskogo gosudarstvennogo universiteta informatiki i radioèlektroniki
The article considers the application of a two-diode physical and mathematical model in the analysis of telemetry data of solar panels using digital twins to monitor the efficiency of solar power plants.
K. S. Dzik, I. V. Gasenkova
doaj   +1 more source

The impact of standard accelerated stability conditions on antibody higher order structure as assessed by mass spectrometry. [PDF]

MAbs, 2019
Kerr RA, Keire DA, Ye H.
europepmc   +1 more source