Results 101 to 110 of about 17,108 (263)

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

Costituzione e discorso delle istituzioni in Cina oggi

Nuovi autoritarismi e democrazie: diritto, istituzioni, società, 2019
In March 2018, the National People’s Congress of China adopted of the fifth amendment to the current constitutional text. In the five years prior to the vote, the CCP and state organs published a series of speeches and documents in order to reaffirm the ...
Bettina Mottura
doaj  

The Role of The Constitutional Court in Maintaining the Balance of Power in Indonesia

Law & Pass
The role of the Constitutional Court in maintaining the balance of power in Indonesia is crucial in ensuring the achievement of a democratic and fair system of government.
Dony Setyawan, Atma Suganda, Supaphorn Akkapin   +2 more
doaj   +1 more source

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source

UNRAVELING THE THREADS OF CONSTITUTIONAL INTERPRETATION: EXPLORING KEY PRINCIPLES

Хабаршы. Заң сериясы
The analysis looks at how each of these principles influences the process of constitutional interpretation and how they may conflict or complement each other.
Д.Б. Махамбетсалиев, А.Б. Ракымгалиева   +1 more
doaj   +1 more source

Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding

FEBS Letters, EarlyView.
In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança, Eline L. Jansen, Jorine M. Eeftens   +2 more
wiley   +1 more source

Functional comparison of EncB and EncC cargo proteins in iron storage within the Myxococcus xanthus encapsulin

FEBS Letters, EarlyView.
Encapsulins are protein nanocompartments that play an important role in iron storage. In the Myxococcus xanthus encapsulin system, two cargo proteins called EncB and EncC contribute to iron mineralization. Here, we show that EncB and EncC generate iron‐containing minerals with distinct chemical compositions, suggesting that the composition of stored ...
Harry B. McDowell, Thomas Walther, Egbert Hoiczyk   +2 more
wiley   +1 more source

Enhanced high-temperature strength in Mo0.5NbTiZrAlx refractory high-entropy alloys via Al addition

Next Materials
The high-temperature phase structure stability and mechanical property evolution of Mo0.5NbTiZrAlx (x = 0.3, 0.5, 0.7) RHEAs were investigated. The experimental results show that with the increase of Al content, the alloy maintains a stable BCC single ...
Qi Gao, Shan Jiang, Jie Yu, Bohang Yang, Shengzhi Hao, Nana Tian   +5 more
doaj   +1 more source

Structural and biochemical analysis of a B12 superbinder

FEBS Letters, EarlyView.
BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices, Jacob J. Whittaker, Dirk J. Slotboom, Albert Guskov   +3 more
wiley   +1 more source

The influence of morpho-anthropogenic indicators on the risk of damage to the musculoskeletal system and the working qualities of dogs

Ветеринария и кормление
It has been established that damage to the musculoskeletal system in sports and working dogs is due to the integration influence of a combination of both exo- and endogenous factors, including biomechanical (hypo- and hyperkinesia), psychoemotional ...
Goncharova D.A., Slesarenko N.A.
doaj   +1 more source