Results 31 to 40 of about 55,626 (234)

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Brief review of the development of theories of robustness, roughness and bifurcations of dynamic systems

Научно-технический вестник информационных технологий, механики и оптики
The development issues of theories of robustness, roughness and bifurcations of dynamic systems are considered. In the modern theory of dynamic systems and automatic control systems, researches of the properties of roughness and robustness of systems are
R. O. Omorov
doaj   +1 more source

On the stability properties of linear dynamic time-varying unforced systems involving switches between parameterizations from topologic considerations via graph theory

Discrete Applied Mathematics, 2007
zbMATH Open Web Interface contents unavailable due to conflicting licenses.
De la Sen, M., Ibeas, A.
openaire   +1 more source

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

FEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young, Omar Arias‐Gaguancela, Fiona Gibson, Morgan Grainger, Jodie Score, Amit Nathubhai, Mauricio Cafiero, Lee Richard Machado   +7 more
wiley   +1 more source

Manifestations of flow topology in a quantum driven-dissipative system

Physical Review Research
Driven-dissipative bosonic systems exhibit a rich variety of nonequilibrium steady states (NESS) due to the interplay between coherent drives, interactions, and dissipation.
Kilian Seibold, Greta Villa, Javier del Pino, Oded Zilberberg   +3 more
doaj   +1 more source

Additive Manufacturing of Continuous Fibre Reinforced Composites: Process, Characterisation, Modelling, and Sustainability

Advanced Engineering Materials, EarlyView.
Additive manufacturing provides precise control over the placement of continuous fibres within polymer matrices, enabling customised mechanical performance in composite components. This article explores processing strategies, mechanical testing, and modelling approaches for additive manufactured continuous fibre‐reinforced composites.
Cherian Thomas, Amir Hosein Sakhaei
wiley   +1 more source

Self-organization in the localised failure regime: metastable attractors and their implications on force chain functionality

EPJ Web of Conferences, 2017
In transitive metastable chaotic dynamical systems, there are no invariant neighbourhoods in the phase space. The best that one can do is look for metastable or almost-invariant (AI) regions as a means to decompose the system into its basic self ...
Pucilowski Sebastian, Tordesillas Antoinette, Froyland Gary   +2 more
doaj   +1 more source

Unleashing the Power of Machine Learning in Nanomedicine Formulation Development

Advanced Functional Materials, EarlyView.
A random forest machine learning model is able to make predictions on nanoparticle attributes of different nanomedicines (i.e. lipid nanoparticles, liposomes, or PLGA nanoparticles) based on microfluidic formulation parameters. Machine learning models are based on a database of nanoparticle formulations, and models are able to generate unique solutions
Thomas L. Moore, Cristiano Pesce, Antonietta Greco, Claudia Pisante, Greta Avancini, Valentina Di Francesco, Yosi Shamay, Paolo Decuzzi   +7 more
wiley   +1 more source

Noise-Induced Transitions in Nonlinear Oscillators: From Quasi-Periodic Stability to Stochastic Chaos

Fractal and Fractional
This paper presents a comprehensive dynamical analysis of a nonlinear oscillator subjected to both deterministic and stochastic excitations. Utilizing a diverse suite of analytical tools—including phase portraits, Poincaré sections, Lyapunov exponents ...
Adil Jhangeer, Atef Abdelkader
doaj   +1 more source

Emergent Spin‐Glass Behavior in an Iron(II)‐Based Metal–Organic Framework Glass

Advanced Functional Materials, EarlyView.
A one‐pot, solvent‐free synthesis yields an Fe2+‐based metal‐organic framework (MOF) glass featuring a continuous random network structure. The material exhibits spin‐glass freezing at 14 K, driven by topological‐disorder and short‐range magnetic frustration, showcasing the potential of MOF glasses as a plattform for cooperative magnetic phenomena in ...
Chinmoy Das, Soma Salamon, Joachim Landers, Jan‐Benedikt Weiß, Wen‐Long Xue, Pascal Kolodzeiski, Roman Pallach, Heiko Wende, Sebastian Henke   +8 more
wiley   +1 more source