Results 101 to 110 of about 1,170,217 (311)

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Uniform stabilization and exact controllability for hyperbolic systems with discontinuous coefficients

Electronic Journal of Differential Equations, 2007
This paper considers a hyperbolic system with discontinuous coefficients in a bounded, open, connected set with smooth boundary and controlled through the Robin boundary condition. Uniform stabilization of the solutions are established.
Boris V. Kapitonov, Felix P. Quispe Gomez   +1 more
doaj  

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Rolling balance board of adjustable geometry as a tool to assess balancing skill and to estimate reaction time delay. [PDF]

J R Soc Interface, 2021
Molnar CA, Zelei A, Insperger T.
europepmc   +1 more source

Optimal feedback control infinite dimensional parabolic evolution systems: Approximation techniques [PDF]

A general approximation framework is discussed for computation of optimal feedback controls in linear quadratic regular problems for nonautonomous parabolic distributed parameter systems.
Banks, H. T., Wang, C.
core   +1 more source

Targeting p38α in cancer: challenges, opportunities, and emerging strategies

Molecular Oncology, EarlyView.
p38α normally regulates cellular stress responses and homeostasis and suppresses malignant transformation. In cancer, however, p38α is co‐opted to drive context‐dependent proliferation and dissemination. p38α also supports key functions in cells of the tumor microenvironment, including fibroblasts, myeloid cells, and T lymphocytes.
Angel R. Nebreda
wiley   +1 more source

Sizing down and functionalizing polylactide (PLA) resin for synthesis of PLA-based polyurethanes for use in biomedical applications. [PDF]

Sci Rep, 2023
Nim B, Rahayu SS, Thananukul K, Eang C, Opaprakasit M, Petchsuk A, Kaewsaneha C, Polpanich D, Opaprakasit P.   +8 more
europepmc   +1 more source

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

Molecular Oncology, EarlyView.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta, Yang Song, Madeleine Ndahayo, Anirudh Saxena, Theresa Guo, Dylan Z. Kelley, Jessica Gore, Andrew Hennigan, Alexa Anderson, John C. Papadimitriou, Daria A. Gaykalova   +10 more
wiley   +1 more source

On stabilizability of the upper equilibrium of the asymmetrically excited inverted pendulum

Electronic Journal of Qualitative Theory of Differential Equations, 2018
Using purely elementary methods, necessary and sufficient conditions are given for the existence of $T$-periodic and $2T$-periodic solutions around the upper equilibrium of the mathematical pendulum when the suspension point is vibrating vertically with ...
László Csizmadia
doaj   +1 more source

Model Predictive Regulation on Manifolds in Euclidean Space. [PDF]

Sensors (Basel), 2022
Phogat KS, Chang DE.
europepmc   +1 more source