Results 121 to 130 of about 853,608 (316)
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
Finite-time stabilization by using degenerate feedback delay
Electronic Journal of Differential Equations, 2015 Some examples are studied in which a linear controllable dynamical system can be steered towards a specific steady state by using some appropriate linear, time-varying delayed feedback controller.
Jose M. Vegas
doaj
Molecular Oncology, EarlyView.Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata +10 more
wiley +1 more source
Molecular Oncology, EarlyView.Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary +1 more
wiley +1 more source
Stabilization Time of Wake Behind Hypersonic Capsule
, 2002 P(論文)A stabilization time of a wake structure behind a hypersonic vehicle is very important in an experiment on the flow structure by using pulsed facilities of high enthalpy or of high Mach number. However, observations themselves of such wake structure
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Molecular Oncology, EarlyView.Both cg12821679MAPRE3 methylation and MAPRE3 expression are significantly associated with overall survival (OS) of non‐small cell lung cancer. Meanwhile, MAPRE3 expression significantly modified the effect of smoking cessation on OS. Smoking cessation benefits OS merely for patients with high MAPRE3 expression.
Chao Chen +14 more
wiley +1 more source
A Model of Exchange-Rate-Based Stabilization for Turkey [PDF]
The literature on the exchange-rate-based stabilization has focused almost exclusively in Latin America. Many other countries however, such as Egypt, Lebanon and Turkey; have undertaken this sort of programs in the last 10-15 years.
Ozlem Aytac
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Health Care Stabilization Fund Bulletin, 2023
, 2023 This internet resource contains bulletins issued throughout several yearsNew surcharge rates effective January 1, 2024 through December 31, 2024. -- Health Care Stabilization Fund Surcharge Rates (Effective January 1, 2024 – December 31, 2024)
Kansas. Board of Governors Health Care Stabilization Fund
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Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
Some Results of Stochastic Differential Equations
AxiomsIn this paper, there are two aims: one is Schauder and Sobolev estimates for the one-dimensional heat equation; the other is the stabilization of differential equations by stochastic feedback control based on discrete-time state observations.
Shuai Guo, Wei Li, Guangying Lv
doaj +1 more source