Results 31 to 40 of about 896,497 (274)
Programmable Protein Stabilization with Language Model-Derived Peptide Guides
Nature CommunicationsAbstract Dysregulated protein degradation via the ubiquitin-proteasomal pathway can induce numerous disease phenotypes, including cancer, neurodegeneration, and diabetes. Stabilizing improperly ubiquitinated proteins via target-specific deubiquitination is thus a critical therapeutic goal.
Lauren Hong +11 more
openaire +5 more sources
Journal of Children's Orthopaedics, 2019 Purpose Diseases such as osteogenesis imperfecta, fibrous dysplasia, hypophosphataemic rickets and others lead to soft and weak bones and long bone deformity in affected patients.
T. Wirth
doaj +1 more source
Degradation mechanism of the von Willebrand factor A2 domain by nattokinase
FEBS Letters, EarlyView.Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto +3 more
wiley +1 more source
Pharmacological inhibition of CLPP stabilizes LETMD1 to boost thermogenesis and alleviate obesity
AdipocyteObesity poses a severe global health burden, and activating adipose thermogenesis offers a promising therapeutic avenue. However, the contribution of mitochondrial proteostasis to thermogenic regulation remains elusive.
Huiwen Yuan +4 more
doaj +1 more source
FEBS Letters, EarlyView.We present robust protocols for the preparation of supported lipid bilayers (SLBs) incorporating either Salmonella smooth LPS or outer membrane vesicles (OMVs). We use a combination of quartz crystal microbalance with dissipation (QCM‐D) and fluorescence microscopy to both characterize the SLBs of various compositions and to probe their interactions ...
Hudson P. Pace +6 more
wiley +1 more source
Kansas Health Care Stabilization Fund General Information [2014]
, 2014 "As of July 1, 2014." "The above information is updated based on enactment of 2014 House Bill 2516. Fund or HCSF means the Health Care Stabilization Fund. Fund law means the Health Care Provider Insurance Availability Act (K.S.A.
Kansas. Health Care Stabilization Fund.
core +1 more source
Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source
FEBS Letters, EarlyView.CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens +8 more
wiley +1 more source
Cadernos de Saúde Pública: Co-infection of tuberculosis (TB)-HIV/AIDS is a persistent public health problem in Brazil. This study describes epidemiological patterns and time trends of mortality related to TB-HIV/AIDS co-infection.
Mauricélia da Silveira Lima +5 more
doaj +1 more source
Studies on colonisation of fly ash disposal sites using invasive species and aromatic grasses
Journal of Environmental Engineering and Landscape Management, 2017 Fly ash disposal activities by coal based thermal power plants will continue to be a serious issue across the globe due to its hiked generation every year.
Deblina Maiti, Bably Prasad
doaj +1 more source