Results 81 to 90 of about 19,088 (218)

Comparing the paths of Hedgehog release in artificial and natural settings

FEBS Letters, EarlyView.
Hh morphogens require solubilization factors to overcome their tight association with the plasma membrane and signal to distant cells, but the precise functions of these factors are controversial. Here, we use published in vivo observations as the most relevant evidence to test their suggested functions and discuss contradictions and gaps between in ...
Janna Puschmann, Kay Grobe
wiley   +1 more source

The effect of changes in fertility on the age distribution of stable populations

Demographic Research, 2009
When fertility increases in a previously stable population, the new stable population will be younger than the old one, and the two age distributions will cross at the mean age of the populations.
Michel Guillot
doaj  

Association Measures in the Bivariate Correlated Frailty Model

Revstat Statistical Journal, 2018
This paper deals with a general bivariate correlated frailty model. This includes the multiplicative as well as the additive frailty effect. The association parameter is studied for the shared as well as the general correlated model. The results for the
Ramesh C. Gupta
doaj   +1 more source

How structural disorder and polyelectrolyte properties of prothymosin α enable its large interactome

FEBS Letters, EarlyView.
In this review, complexes of the fully disordered and highly negatively charged prothymosin α are collected, described, and discussed. Linked to its poly‐electrostatic character, prothymosin α engages a large interactome through multiple different binding modes ranging from fully disordered complexes to short linear motif (SLiM)‐driven interactions ...
Ketty C. Tamburrini, Freia S. Buus, Benjamin Schuler, Birthe B. Kragelund   +3 more
wiley   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Phased Fractional Low-Order Moment-Based Doppler Shift Estimation in the Presence of Interference Signals and Impulsive Noise

Fractal and Fractional
Doppler shift estimation continues to be a critical challenge of utmost significance in both theoretical research and practical engineering applications.
Bo Ni, Mengjia Wang, Jiacheng Zhang, Ying Zhang, Tao Liu   +4 more
doaj   +1 more source

Network Actual Traffic Prediction Algorithm Based on α-stable Distribution and Wavelet Transformation

Cybernetics and Information Technologies, 2015
In order to improve the prediction precision of wireless sensor network traffic, a new prediction algorithm (State Prediction algorithm based on α-stable distribution α, SP-α) is proposed, combined with α-stable distribution and wavelet transformation ...
Chen Guobin, Luo Nanying
doaj   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

Conditional Distributions and Characterizations of Multivariate Stable Distribution

Journal of Multivariate Analysis, 1995
Let \(X\) and \(Y\) be two identically distributed random variables. \textit{M. Ahsanullah} [Metrika 32, 215-218 (1985; Zbl 0609.62019)] showed that if the conditional distribution of \(X|Y=y\) is a normal distribution with mean \(ay+b\) and with variance \(\sigma^2\), then \(|a|
openaire   +2 more sources