Results 191 to 200 of about 3,027,054 (295)

Conserved Asp233-Asp246 hydrogen bond modulates active site dynamics in class A β-lactamases. [PDF]

Protein Sci
Lopez-Gallego CV, Timmer M, Vreede J, Ubbink M.   +3 more
europepmc   +1 more source

ATZ‐1 promotes DNA replication efficiency to maintain normal meiotic function

FEBS Open Bio, EarlyView.
Absence of ATZ‐1 interferes with meiotic DNA replication and cell cycle function via CHK‐1. This causes downstream defects associated with DNA damage and genomic integrity. Taken together, this study suggests that ATZ‐1 influences DNA replication efficiency and cell cycle function to maintain normal meiotic function.
Taylin E. Gourley, Luke W. Molesworth, Nethma H. Waduge, Fahimeh Eskandari, Peter R. Boag, Gregory M. Davis   +5 more
wiley   +1 more source

Single-Chain Conformational Fluctuation Regulates Phase Separation of Intrinsically Disordered Proteins. [PDF]

JACS Au
Feng C, Xu S, Su H, Chu X.
europepmc   +1 more source

Accurate and noninvasive prostate cancer detection using plasma‐derived extracellular vesicle RNA

FEBS Open Bio, EarlyView.
Plasma extracellular vesicles were captured with WGA‐conjugated magnetic beads and profiled for RNA biomarkers. A three‐RNA panel (NM_024955, NR_047469, and NR_002564) distinguished prostate cancer from healthy controls and benign prostatic hyperplasia, supporting a simple, noninvasive approach to improve prostate cancer detection.
Hanping Wei, Haoran Wu, Wei Feng
wiley   +1 more source

A comprehensive assessment of climate and topographic changes to identify conservation gaps for the critically endangered species <i>Coptis teeta</i> Wall in southwest China. [PDF]

Front Plant Sci
Li R, Wang X, Chen W, Wang Y, Zhou Y, Zhou J, Xu K, Qi X, Huang Z.   +8 more
europepmc   +1 more source

Multivariate stable distributions

This paper is devoted to the theory and application of multidimensional stable distributions. Properties of these laws are developed and explicit algebraic representations are given in terms of characteristic functions.
Press, S. J.
core  

Evolution‐guided yeast complementation reveals functional differences in human PSPH variants

FEBS Open Bio, EarlyView.
Ancient genomes can help guide which human genetic variants are tested experimentally. This study applies that idea to PSPH, a gene involved in serine biosynthesis, and uses high‐throughput yeast complementation to compare variant function. The findings reveal measurable differences among selected alleles and illustrate the value of evolution‐guided ...
Mauricio Campa‐Álvarez, Diana Ascencio, Miguel Vallebueno‐Estrada, Eduardo González‐Orozco, Christian Eduardo Martínez‐Guerrero, Rafael Montiel, Alexander DeLuna   +6 more
wiley   +1 more source

Generative Adversarial Networks for Omics Data: An Overview and Future Directions for Livestock Applications. [PDF]

Anim Genet
Vargas EC, Bresolin T.
europepmc   +1 more source

Identifying and characterising a plant GH1 β‐glucosidase that exhibits hydrolytic activity on N‐linked glucopyranoside

FEBS Open Bio, EarlyView.
We report the first β‐glucosidase with demonstrated hydrolytic activity on an N‐linked glycopyranoside. The enzyme, native to maize, was biochemically characterised for this novel reaction, and structural modelling of the enzyme–substrate complex revealed several clues to the underlying reduced catalytic rate relative to its native O‐glycopyranoside ...
Hani Gharabli, Carlotta Chiesa, Maher Abou Hachem, Ditte Hededam Welner   +3 more
wiley   +1 more source

Fast-Forward: Automatic Assignment and Assessment of Bonded Parameters for the Martini Force Field. [PDF]

J Chem Inf Model
Brasnett C, Fidlin M, Duve T, Thallmair S, Marrink SJ, Grünewald F.   +5 more
europepmc   +1 more source