Results 151 to 160 of about 139,467 (313)

Structure‐Guided Engineering of a Promiscuous O‐Methyltransferase for a SAM Regeneration Biocatalysis Platform of Methylated Pharmaceuticals

open access: yesAdvanced Science, EarlyView.
A substrate promiscuous and regioselective O‐methyltransferase, SmOMT, is functionally and structurally characterized. A double mutant, SmOMTE152A/I306A, exhibited enhanced catalytic activity. By coupling this mutant with a mutant halide methyltransferase, AtHMTV140T, for SAM regeneration, a superior artificial fusion enzyme, AtHMTV140T‐L95‐SmOMTE152A ...
Xiran Xiong   +11 more
wiley   +1 more source

Mechanisms of Aristolochic Acid Resistance in Specialist Butterflies and Evolutionary Insights for Potential Protective Pathways

open access: yesAdvanced Science, EarlyView.
The study provides an extreme example of insect adaptation to highly toxic defenses of host plants, and investigates the complex strategies to resist carcinogenic aristolochic acids, including physical isolation, metabolic detoxification, and DNA repair.
Yang Luan   +20 more
wiley   +1 more source

Protocol to assess retinal metabolic flux of mice via stable isotope-resolved metabolomics. [PDF]

open access: yesSTAR Protoc
Komissarov G   +8 more
europepmc   +1 more source

Stable isotope record of Uvigerina peregrina from the Mediterranean Sea

open access: gold, 1991
Vergnaud-Grazzini, Colette   +1 more
openalex  

(Table 1) Selected samples from ODP Site 175-1075 subjected to compound specific stable carbon isotope analysis

open access: green, 1997
Helen M. Talbot   +9 more
openalex   +1 more source

Microdroplet Stabilization Enabled Direct Mass Spectrometric Identification of Electrogenerated Transient Carbocation Intermediates

open access: yesAdvanced Science, EarlyView.
The in situ mass spectrometric identification of the electrogenerated benzylic and phenylic carbocations, whose half‐lives in bulk solutions are on the nanosecond scale, is achieved by taking advantage of the unique stabilization effect of the electrosprayed microdroplets.
Guo‐Shan Zhu, Ren‐Jie Hui, Jun Hu
wiley   +1 more source

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