Results 31 to 40 of about 64,264 (235)

Stable carbon isotope discrimination by human 3-hydroxy-3-methylglutaryl-coenzyme A reductase

Journal of Lipid Research, 2008
The aim of this study was to investigate the possible existence and magnitude of stable carbon isotope discrimination by human 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMGR). The catalytic portion of HMGR was expressed and purified.
Svena M. Lüdke, Ulrich Flenker, Wilhelm Schänzer, Dietmar Schomburg   +3 more
doaj   +1 more source

Discovery and Targeted Proteomic Studies Reveal Striatal Markers Validated for Huntington's Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Clinical trials for Huntington's disease (HD) enrolling persons before clinical motor diagnosis (CMD) lack validated biomarkers. This study aimed to conduct an unbiased discovery analysis and a targeted examination of proteomic biomarkers scrutinized by clinical validation. Methods Cerebrospinal fluid was obtained from PREDICT‐HD and
Daniel Chelsky, Cara Joyce, H. Jeremy Bockholt, Paul A. Rudnick, William H. Adams, Fiona McAllister, Justin W. Smock, Michael A. Newton, Jane S. Paulsen   +8 more
wiley   +1 more source

CSF Monoamine Metabolites and Cognitive Trajectory in Early Parkinson's Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Imaging and postmortem studies indicate that abnormalities in monoaminergic neurotransmission contribute to cognitive impairment in Parkinson's disease (PD). However, it remains uncertain if cerebrospinal fluid (CSF) monoamine metabolites can serve as biomarkers of cognitive decline in early PD.
Jing‐Yu Shao, Rong Li, Yu‐Xiang Jiao, Kai Ma, Hong‐Qi Yang, Zheng‐Yu Sun, Jie‐Wen Zhang, Shuai Chen   +7 more
wiley   +1 more source

Selective and Precise Editing of Digital Polymers Through Parallel or Series Toehold‐Mediated Strand Displacement

Advanced Functional Materials, EarlyView.
A sequence‐encoded supramolecular construct containing two accessible toeholds is developed herein for enabling multiple editing operations. By introducing specific input strands, it is possible to selectively erase or rewrite digital content through parallel or series toehold‐mediated strand displacement (PTMSD or STMSD).
Jakub Ossowski, Cyril Antheaume, Jean‐François Lutz, Maria Nerantzaki   +3 more
wiley   +1 more source

Electroactive Metal–Organic Frameworks for Electrocatalysis

Advanced Functional Materials, EarlyView.
Electrocatalysis is crucial in sustainable energy conversion as it enables efficient chemical transformations. The review discusses how metal–organic frameworks can revolutionize this field by offering tailorable structures and active site tunability, enabling efficient and selective electrocatalytic processes.
Irena Senkovska, Yutong Luo, Ruyan Zhao, Jianjun Zhang, Mingchao Wang, Xinliang Feng, Eike Brunner, Stefan Kaskel   +7 more
wiley   +1 more source

Working standards and analytical framework for CSIA: isotopic composition (δ13C, δ15N, and δ34S) of 21 amino acids and 7 nucleobases

Progress in Earth and Planetary Science
We determined the carbon and nitrogen isotope compositions of biologically important 21 amino acids and 7 nucleobases, which are used as working standards. These isotopic compositions were determined using a high-sensitivity elemental analyzer coupled to
Nanako O. Ogawa, Yoshinori Takano, Yu Itahashi, Naoto F. Ishikawa, Naohiko Ohkouchi   +4 more
doaj   +1 more source

Arsenic Species and Nitrogen Stable Isotope Ratios in the Japanese Diet—Dietary Markers of Seafood

Foods
Interest in seafood diet and health warrants a biomarker for seafood consumption. Nitrogen isotope ratio (15N/14N, expressed as δ15N (‰)) has been regarded as a biomarker for such a purpose.
Jun Yoshinaga, Tomohiro Narukawa
doaj   +1 more source

Unraveling the Mg Loss Mechanism and Degradation Kinetics in Thermoelectric n‐Type Mg2Si‐Mg2Sn Solid Solutions

Advanced Functional Materials, EarlyView.
Mg‐based thermoelectrics are among the most promising candidates for power generation applications but their performance is compromised by Mg loss at device operation temperatures due to the higher chemical potential of Mg (μMg${\mu}_{\mathrm{Mg}}$) inside the material compared to the environment.
Aryan Sankhla, Eckhard Mueller, Johannes de Boor   +2 more
wiley   +1 more source

Emerging techniques in vegetable oil analysis using stable isotope ratio mass spectrometry

Grasas y Aceites, 2002
As the practice of vegetable oil adulteration becomes more sophisticated, the possibility to subvert detection using established techniques such as capillary gas chromatography is increasing.
Simon D. Kelly, Christopher Rhodes
doaj   +1 more source

Mass spectrometric measurement of hydrogen isotope fractionation for the reactions of chloromethane with OH and Cl [PDF]

Atmospheric Chemistry and Physics, 2018
Chloromethane (CH3Cl) is an important provider of chlorine to the stratosphere but detailed knowledge of its budget is missing. Stable isotope analysis is a potentially powerful tool to constrain CH3Cl flux estimates.
F. Keppler, F. Keppler, F. Keppler, E. Bahlmann, E. Bahlmann, M. Greule, M. Greule, H. F. Schöler, J. Wittmer, J. Wittmer, C. Zetzsch, C. Zetzsch   +11 more
doaj   +1 more source