Results 61 to 70 of about 612,314 (336)
Discovery and Targeted Proteomic Studies Reveal Striatal Markers Validated for Huntington's Disease
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Clinical trials for Huntington's disease (HD) enrolling persons before clinical motor diagnosis (CMD) lack validated biomarkers. This study aimed to conduct an unbiased discovery analysis and a targeted examination of proteomic biomarkers scrutinized by clinical validation. Methods Cerebrospinal fluid was obtained from PREDICT‐HD and
Daniel Chelsky +8 more
wiley +1 more source
Sr-isotope analysis of speleothems by LA-MC-ICP-MS: High temporal resolution and fast data acquisition [PDF]
, 2017 Speleothems are well established climate archives. A wide array of geochemical proxies, including stable isotopes and trace elements are present within speleothems to reconstruct past climate variability.
Breitenbach, Sebastian +5 more
core +3 more sources
CSF Monoamine Metabolites and Cognitive Trajectory in Early Parkinson's Disease
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Background Imaging and postmortem studies indicate that abnormalities in monoaminergic neurotransmission contribute to cognitive impairment in Parkinson's disease (PD). However, it remains uncertain if cerebrospinal fluid (CSF) monoamine metabolites can serve as biomarkers of cognitive decline in early PD.
Jing‐Yu Shao +7 more
wiley +1 more source
Fingerprint analysis of biological samples using ICP-MS and IR-MS [PDF]
, 2012 Atomic spectroscopy based analytical techniques can generate fingerprints encompassing the vast majority of elements found in the periodic table as well as ratios of their stable isotopes. These highly multivariate fingerprints have laid the foundation
Husted, Søren, Laursen, Kristian Holst
core
No influence of CO2 on stable isotope analyses of soil waters with OA-ICOS [PDF]
, 2017 Acknowledgements We are thankful for the support by Audrey Innes with the stable isotope, LOI, and GWC analysis. We thank Jonathan Dick for suggesting that we use sparkling water to generate different CO2 concentrations in the headspace and Claire ...
Allison +29 more
core +1 more source
Deterministic Detection of Single Ion Implantation
Advanced Engineering Materials, EarlyView.Focused ion beam implantation with high detection efficiencies will enable the rapid and scalable fabrication of advanced spin‐based technologies such as qubits. This work presents the detection efficiencies of a wide range of ions implanted into solid‐state hosts, with efficiencies of >90% recorded for ion species and substrate combinations of ...
Mason Adshead +6 more
wiley +1 more source
Advanced Functional Materials, EarlyView.A sequence‐encoded supramolecular construct containing two accessible toeholds is developed herein for enabling multiple editing operations. By introducing specific input strands, it is possible to selectively erase or rewrite digital content through parallel or series toehold‐mediated strand displacement (PTMSD or STMSD).
Jakub Ossowski +3 more
wiley +1 more source
Progress in Earth and Planetary ScienceWe determined the carbon and nitrogen isotope compositions of biologically important 21 amino acids and 7 nucleobases, which are used as working standards. These isotopic compositions were determined using a high-sensitivity elemental analyzer coupled to
Nanako O. Ogawa +4 more
doaj +1 more source
Arsenic Species and Nitrogen Stable Isotope Ratios in the Japanese Diet—Dietary Markers of Seafood
FoodsInterest in seafood diet and health warrants a biomarker for seafood consumption. Nitrogen isotope ratio (15N/14N, expressed as δ15N (‰)) has been regarded as a biomarker for such a purpose.
Jun Yoshinaga, Tomohiro Narukawa
doaj +1 more source
Intercomparison of soil pore water extraction methods for stable isotope analysis [PDF]
, 2016 Funded by NSERC Discovery Grant U.S. Forest Service U.S. Department of Energy's Office of Energy Efficiency and Renewable Energy, Bioenergy Technologies OfficePeer ...
McDonnell, Jeffery J. +2 more
core +1 more source