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Stable Isotope Tracers for Metabolic Pathway Analysis
2019Stable isotope tracing allows a metabolic substrate to be followed through downstream biochemical reactions, thereby providing unparalleled insights into the metabolic wiring of cells. This approach stops short of modeling absolute fluxes but is relatively straightforward and has become increasingly accessible due to the widespread adoption of high ...
Sara, Violante +3 more
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In-vivo Measurement of Glucose and Alanine Metabolism with Stable Isotopic Tracers
Diabetes, 1977This report describes sensitive, precise microtechniques that allow quantification of glucose and alanine metabolism in vivo using stable isotope tracers. By combined gas chromatography-mass spectrometry and selected ion monitoring—deuterium and carbon-13 enrichment in blood glucose and alanine were measured with an error of less than 2 per cent ...
D M, Bier +5 more
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Availability of stable isotope tracers for human use
European Journal of Pediatrics, 1997Stable isotope tracers do not have approval for diagnostic use in humans. We assume that stable isotope tracers behave like natural compounds, because there is no evidence for the opposite despite a wide use in human studies. From this point of view, they are drugs comparable to unlabelled natural substances. Under this assumption a pharmacy is allowed
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Analysis of stable-isotope tracers by proton scattering
Nuclear Instruments and Methods, 1980Abstract The availability of proton elastic scattering for the analysis method of stable isotopes was investigated with proton beams of a tandem accelerator. Attention has been paid to target backing, selection of incident energy and detection system for scattered protons for obtaining sharp peaks of elastic scattering protons from stable isotopes ...
Shinji Matsumoto +3 more
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Stable isotope tracers for studies of glucose metabolism.
The Journal of laboratory and clinical medicine, 1990Because of its unique metabolism, glucose illustrates the advantages and limitations of stable isotopic tracers for in vivo studies. The present review describes the application of stable tracers in studies of glucose metabolism. The natural abundance of these tracers requires that careful attention be given to the dose of the tracer and the impact of ...
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Stable isotope tracer methods for in vivo investigations.
Federation proceedings, 1982During the last two decades, in parallel with the growth of modern electronics, several new techniques have been developed for measuring stable isotopic enrichments in biochemistry and medicine. The development and potential of these techniques are discussed.
D M, Bier, D E, Matthews
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The determination of radioactive and stable tracer isotopes
The Analyst, 1948A. G. Maddock +4 more
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Stable isotope ratio analysis of lactose as a possible potential geographical tracer of milk
Food Control, 2022Matteo Perini, Federica Camin
exaly