Results 131 to 140 of about 2,269,629 (300)

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Comparative outcomes with low-dose and standard-dose immune checkpoint inhibitors in microsatellite stable advanced gastric/gastroesophageal adenocarcinoma☆

ESMO Gastrointestinal Oncology
Background: The combination of chemotherapy and immune checkpoint inhibitors (ICIs) is usually considered standard in advanced gastric/gastroesophageal adenocarcinoma (GC) with combined positive score (CPS) 6≥5.
A. Ramaswamy, V. Shenoy, A. Bahl, A. Rauthan, V.M. Krishna, V. Talwar, V. Agarwala, A. Kapoor, R. Pinninti, M. Sharma, S.J. Rajappa, N. Rohatgi, A. Khan, A. Jain, U. Batra, R.K. Kaushal, M.V. Chandrakanth, B. Sansar, A. Gupta, P. Bhargava, V. Ostwal   +20 more
doaj   +1 more source

Inflation Targeting, Price-Path Targeting and Output Variability [PDF]

The dramatic improvement in macroeconomic outcomes during the 1990s - stable, low inflation and high, stable growth - can be at least partly ascribed to improved monetary policy.
Junhan Kim, Stephen G. Cecchetti
core  

Infrared laser sampling of low volumes combined with shotgun lipidomics reveals lipid markers in palatine tonsil carcinoma

Molecular Oncology, EarlyView.
Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff, Manuela Moritz, Dennis Eggert, Anna Worthmann, Joerg Heeren, Henrike Zech, Till S. Clauditz, Waldemar Wilczak, Hartmut Schlüter, Christian S. Betz, Arne Böttcher, Jan Hahn   +11 more
wiley   +1 more source

Pulse pressure associates with severity and worse outcomes in patients with stable coronary artery disease

npj Cardiovascular Health
The association of pulse pressure (PP) with the severity and cardiovascular (CV) outcomes in stable coronary artery disease populations with normal ejection fraction are sparse.
Yan Zhang, Sha Li, Hui-Wen Zhang, Yuan-Lin Guo, Na-Qiong Wu, Cheng-Gang Zhu, Rui-Xia Xu, Jie Qian, Ke-Fei Dou, Jian-Jun Li   +9 more
doaj   +1 more source

Stable or Unstable? Evaluating the Strength Outcomes of 12-Week Resistance Training in Youth Judo Athletes

Sports
Background: The purpose of this study was to compare the effects of resistance training on stable versus unstable surfaces on strength performance in young judokas.
Nemanja Stanković, Dušan Stupar, Aleksandar Ignjatović, Nikola Milošević, Nebojša Trajković   +4 more
doaj   +1 more source

Managing Wildlife Faced with Pathogen Risks Involving Multi-Stable Outcomes. [PDF]

Environ Resour Econ (Dordr), 2018
Horan RD, Finnoff D, Berry K, Reeling C, Shogren JF.   +4 more
europepmc   +1 more source

Phenotypic and genotypic characterization of single circulating tumor cells in the follow‐up of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon, Rui P. L. Neves, Nikolas H. Stoecklein, Sven‐Thorsten Liffers, Jens Siveke, Jan D. Kuhlmann, Pauline Wimberger, Paul Buderath, Rainer Kimmig, Sabine Kasimir‐Bauer   +9 more
wiley   +1 more source

Associations of hemoglobin trajectories and time in target hemoglobin range with adverse pregnancy outcomes: a real-world pregnancy records-based study

Frontiers in Global Women's Health
ObjectiveThis study aimed to evaluate associations of hemoglobin trajectories during pregnancy and time spent within clinically recommended hemoglobin ranges (Hb-TITR) with adverse pregnancy outcomes.MethodsA retrospective cohort study was conducted ...
Pinggui Zhang, Yuting Shen, Gang Zou, Xinli Xiang   +3 more
doaj   +1 more source