Results 61 to 70 of about 37,332 (211)
Long Memory and Long Run Variation [PDF]
May 2008 A commonly used defining property of long memory time series is the power law decay of the autocovariance function. Some alternative methods of deriving this property are considered working from the alternate definition in terms of a fractional ...
Peter C.B. Phillips
core
Tail Copula Estimation for Heteroscedastic Extremes [PDF]
Consider independent multivariate random vectors which follow the same copula, but where each marginal distribution is allowed to be non-stationary. This non-stationarity is for each marginal governed by a scedasis function (see Einmahl et al.
Zhou, C., Einmahl, John
core +5 more sources
FEBS Open Bio, EarlyView.Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane +11 more
wiley +1 more source
Characterization and construction of max-stable processes [PDF]
, 2013 Max-stable processes provide a natural framework to model spatial extremal scenarios. Appropriate summary statistics include the extremal coefficients and the (upper) tail dependence coefficients. In this thesis, the full set of extremal coefficients of
Strokorb, Kirstin
core +1 more source
YIPFα1A expression is regulated by multilayered molecular mechanisms
FEBS Open Bio, EarlyView.YIPFα1A, a five‐pass Golgi protein, is regulated at multiple layers. (1) Rare‐codon enrichment drives translation‐coupled mRNA decay. (2) A proximal 3′‐UTR element stabilizes mRNA. (3) A distal 3′‐UTR element included by alternate poly(A) site usage represses translation, which can be overridden by the proximal 3′‐UTR element.
Tokio Takaji +2 more
wiley +1 more source
Optimizing photoactivation of PA‐mCherry for optical pooled CRISPR screens
FEBS Open Bio, EarlyView.Photoactivatable PA‐mCherry finds widespread use to optically tag individual cells. However, confocal 405 nm UV laser‐scanning (normal scan) is much less efficient than widefield UV illumination, limiting the use of PA‐mCherry on confocal instruments. We remedy this limitation by reporting that rapid and repeated confocal scanning with a low‐intensity,
Sravasti Mukherjee +3 more
wiley +1 more source
Studies of Rank and Tail Dependence Represented by Copula Function [PDF]
, 2009 变量间的相关结构是考察变量联合分布特征的首要任务。最经典的是线性相关系数,然而由于线性相关系数是建立在正态分布假设基础上的,存在着很多的局限性,所以,引入了用COPulA函数表示的秩相关和尾相关测度。用COPulA函数表示的秩相关和尾相关测度比较稳健,不易受极端值影响,且不需要正态分布假设。最后通过模拟得到了上市公司T-COP-ulA的秩相关和尾相关测度。To describe joint distribution's characters,the first step is seeing about ...
籍艳丽
core
Molecular characterization of covRS mutations in M1UK Streptococcus pyogenes
FEBS Open Bio, EarlyView.Group A Streptococcus (GAS) acquires covRS mutations driving a hypervirulent bacterial state, frequently associated with invasive disease‐like necrotizing fasciitis. We demonstrate that the newly emerged M1UK GAS lineage can also acquire these mutations.
Jarrad Pritchard +12 more
wiley +1 more source
A Test for the Portion of Bivariate Dependence in Multivariate Tail Risk [PDF]
, 2014 In practice, multivariate dependencies between extreme risks are often only assessed in a pairwise way. We propose a test to detect when tail dependence is truly high-dimensional and bivariate simplifications would produce misleading results. This occurs
Bormann, C. +6 more
core
Transcripts enriched in codons that trigger P‐site tRNA‐mediated mRNA decay possess stable mRNA
FEBS Open Bio, EarlyView.PTMD codons were first described by Mendel et al. as mediators of an mRNA decay pathway dependent on the human protein CNOT3, homologous to yeast Not5. Our findings confirm that PTMD codons destabilize transcripts; however, unlike in yeast, the human pathway specifically targets and slightly destabilizes primarily stable mRNAs.
Rodolfo Lopes Carneiro +1 more
wiley +1 more source