Results 91 to 100 of about 3,846,815 (245)

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

FEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka, Yuxi Liu, Stefano Maggi, Debnath Ghosal, Jue Wang, Prashant P. Damke, Stephen D. Carter, Wei Zhao, Sukhithasri Vijayrajratnam, Joseph P. Vogel, Carrie L. Shaffer, Grant J. Jensen   +11 more
wiley   +1 more source

Effects of maturity stage and mancozeb on phyllosphere microbial communities and the plant health potential of silage maize

Frontiers in Plant Science
Mancozeb is often used to supplement the nutritional requirements of maize for elements such as manganese and zinc, as well as for the control of diseases such as large blotches and stripe blotches.
Qingbiao Xu, Qingbiao Xu, Qiu Yang, Xianli Lu, Shaoshen He, Xueling Ma, Dan Wu, Yuanyan Meng, Liuxing Xu, Liuxing Xu   +9 more
doaj   +1 more source

Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions

FEBS Letters, EarlyView.
We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva, Puspa Kunwar, Md Ibnul Rifat Rahman, Joanna Koryo Kwao, Nathan Lehman, Zihan Zhang, Trenton Paul, Claire Cheng, Nicholas Truex, Hui‐Ting Lee, Jun Zhang   +10 more
wiley   +1 more source

The clinicopathologic patterns of Hodgkin’s lymphoma in Lagos, Nigeria: A retrospective study

Journal of Clinical Sciences
Background: Hodgkin’s lymphoma is a malignant tumor of the lymph nodes that causes painless lymphadenopathy. Diagnosing it can be challenging, especially in the early stages, due to often nonspecific symptoms.
Nicholas Awodele Awolola, Olakanmi Ralph Akinde, Andrea Oludolapo Akinjo, Babatunde Akinola Bamigboye, Vincent Oluseye Osunkalu, Olugbende Obazee Ajayi   +5 more
doaj   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

Anthony McCosker: Intensive Media. Aversive Affect and Visual Culture, New York: Palgrave Macmillan. 2013 og Tova Benski & Eran Fisher (Eds): Internet and Emotions. New York: Routledge. 2013

MedieKultur: Journal of Media and Communication Research, 2014
Carsten Stage
doaj   +3 more sources

Arts-based Teaching: A Pedagogy of Imagination and a Conduit to a Socially Just Education

Current Issues in Education, 2009
“When all is said and done,” contends Hammond (1997), “what matters most for students’ learning are the commitments and capacities of their teachers.” This paper examines how 53 teachers gained, through arts-based professional development ...
Gail Humphries Mardirosian, sarah irvine belson, Yvonne Pelletier Lewis   +2 more
doaj  

PICALM::MLLT10 translocated leukemia

FEBS Letters, EarlyView.
This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen, Antonia C. Nakatsugawa, Natalie Barton, Henry Haines, Gary S. Stein, Janet L. Stein, Daniel S. Wechsler, Jessica L. Heath   +7 more
wiley   +1 more source

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source