Results 61 to 70 of about 3,846,815 (245)

Predicting deamidation and isomerization sites in therapeutic antibodies using structure-based in silico approaches

mAbs
Asparagine (Asn) deamidation and aspartic acid (Asp) isomerization are common degradation pathways that affect the stability of therapeutic antibodies. These modifications can pose a significant challenge in the development of biopharmaceuticals. As such,
David Hoffmann, Joschka Bauer, Markus Kossner, Andrew Henry, Anne R. Karow-Zwick, Giuseppe Licari   +5 more
doaj   +1 more source

Adjunctive Therapeutic Plasma Exchange in Refractory Adult‐Onset Still's Disease Complicated by Secondary Macrophage Activation Syndrome: A Single‐Center Experience

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Introduction Adult‐onset Still's disease (AOSD) complicated by macrophage activation syndrome (MAS) carries substantial mortality. The role of therapeutic plasma exchange (TPE) remains uncertain. Methods We retrospectively analyzed patients with AOSD‐MAS treated with TPE at a single‐center.
Masataka Ueda, Tomohiro Saito, Masahide Mizobuchi, Tomoki Shimomura, Saki Kawamori, Mitsuru Kawanishi, Natsuko Hattori, Jo Sugiyama, Satoshi Tsubata, Hanami Horiguchi, Kazuki Abe, Nao Iida, Yuki Kajio, Nao Oguro, Ryo Yanai, Hirokazu Honda   +15 more
wiley   +1 more source

Perspectives on meaningful dementia treatment and care from those with lived experience

Alzheimer’s & Dementia: Translational Research & Clinical Interventions
The ongoing conversations surrounding the importance of minimal clinically important differences and descriptions of meaningful impacts must include the voices of those living with Alzheimer's disease and related dementias.
Walter Moczygemba, Darlene Bradley, Ralph Carmona, Vinny Celano, Leah Farley, Samuel Valverde, Anna Sampley, Lauren Stratton   +7 more
doaj   +1 more source

Paraneoplastic Lupus Nephritis in a Child With Neuroblastoma Recurrence

Pediatric Blood &Cancer, EarlyView.
Gabriele Mortari, Caterina Costagliola, Marta Nebiolo, Francesca Parisi, Martina Morini, Katia Mazzocco, Gabriele Gaggero, Stefano Volpi, Stefania Sorrentino, Virginia Livellara   +9 more
wiley   +1 more source

Revealing the structure of land plant photosystem II: the journey from negative‐stain EM to cryo‐EM

FEBS Letters, EarlyView.
Advances in cryo‐EM have revealed the detailed structure of Photosystem II, a key protein complex driving photosynthesis. This review traces the journey from early low‐resolution images to high‐resolution models, highlighting how these discoveries deepen our understanding of light harvesting and energy conversion in plants.
Roman Kouřil
wiley   +1 more source

Socialkonstruktivisme, sprog og identitet: Identitetsforhandlinger på Eva Dien Brine Markvoorts sygdomsblog 65 Red Roses

Skandinaviske Sprogstudier, 2015
Socialkonstruktivismen har været genstand for heftig kritik for at understøtte en form for begrebsrelativisme, der påstår, at virkeligheden skabes af vores begreber om den.
Carsten Stage
doaj  

Development of a protocol complexity tool: a framework designed to stimulate discussion and simplify study design

BMC Medical Research Methodology
Background Over the last decade, the pharmaceutical industry has witnessed longer, more complex, and expensive clinical trials. This complexity contributes to delays in clinical trial implementation, execution, monitoring, recruitment, data cleaning, and
Bartholomeus J.A. Willigers, Agata E Wiesiolek, Bruce Potter, Alina Pszczółkowska, Cecilia Kristensson , Veronica Presz , Gabriela Luporini Saraiva, Ioannis Psallidas   +7 more
doaj   +1 more source

Mapping the evolution of mitochondrial complex I through structural variation

FEBS Letters, EarlyView.
Respiratory complex I (CI) is crucial for bioenergetic metabolism in many prokaryotes and eukaryotes. It is composed of a conserved set of core subunits and additional accessory subunits that vary depending on the organism. Here, we categorize CI subunits from available structures to map the evolution of CI across eukaryotes. Respiratory complex I (CI)
Dong‐Woo Shin, Tingting Chen, James A. Letts   +2 more
wiley   +1 more source

Monostotic Fibrous Dysplasia of the Rib: A Case Report

Case Reports in Orthopedics, 2012
Fibrous dysplasia is a noninherited bone disease in which abnormal differentiation of osteoblasts leads to replacement of normal marrow and cancellous bone by immature bone with fibrous stroma.
Asha Mahadevappa, Sapna Patel, Sunila Ravishankar, Gubbanna V. Manjunath   +3 more
doaj   +1 more source

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source