Results 231 to 240 of about 5,493,736 (306)

Promiscuous stimulation of HSP70 ATPase activity by parasite‐derived J‐domains

FEBS Open Bio, EarlyView.
The malaria parasite Plasmodium falciparum exports three highly homologous yet functionally divergent J‐domain proteins into human erythrocytes. Here, we show that J‐domains isolated from all three proteins effectively stimulate the ATPase activity of both endogenous host and exported parasite HSP70 chaperones.
Julian Barth, Moritz Koch, Le‐Han Rössner, Johanna Eichhorn, Denys Pogoryelov, Matthias P. Mayer, Jude M. Przyborski   +6 more
wiley   +1 more source

Transforming a fragile protein helix into an ultrastable scaffold via a hierarchical AI and chemistry framework. [PDF]

Elife
Qiu J, Tang G, Feng T, Zheng B, Liu Y, Zheng P.   +5 more
europepmc   +1 more source

Applicability of mitotic figure counting by deep learning: a development and pan‐cancer validation study

FEBS Open Bio, EarlyView.
In this study, we developed a deep learning method for mitotic figure counting in H&E‐stained whole‐slide images and evaluated its prognostic impact in 13 external validation cohorts from seven different cancer types. Patients with more mitotic figures per mm2 had significantly worse patient outcome in all the studied cancer types except colorectal ...
Joakim Kalsnes, Maria X. Isaksen, Frida Julbø, Manohar Pradhan, Andreas Kleppe, Sepp De Raedt, Ole‐Johan Skrede, Turid Torheim, John Arne Nesheim, Hans Martin Mohn, Hanne A. Askautrud, Karolina Cyll, Wanja Kildal, Emma Rewcastle, Melinda Lillesand, Vebjørn Kvikstad, Emiel Janssen, Robert Jones, Odd Terje Brustugun, Bjørn Brennhovd, Erik Skaaheim Haug, Lill‐Tove Rasmussen Busund, Elin Richardsen, Sigve Andersen, Tom Dønnem, Kristina Lindemann, Gunnar Kristensen, Neil A. Shepherd, Marco Novelli, Knut Liestøl, David Kerr, Håvard E. Danielsen, Tarjei S. Hveem   +32 more
wiley   +1 more source

Being Concerned with Substances of Concern: A Classification of Ethical Dilemmas in Circular Product Design. [PDF]

Sci Eng Ethics
Krstulović I.
europepmc   +1 more source

Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies

FEBS Open Bio, EarlyView.
We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli, Mohammad Nour Alsamsam, Ugnė Bagdonaitė, Van Truc Vu, Chun‐Jen Huang, Polina Kuzhir, Mindaugas Zaremba, Aurimas Kopūstas, Marijonas Tutkus   +8 more
wiley   +1 more source

Translating behavioral interventions into virtual reality: the <i>Transcend Framework</i> for immersive health design. [PDF]

Front Digit Health
Hernandez R, Solai K, Kwon S, Venkatesan P, Fast D, Lara-Cinisomo S, Nisar HJ.   +6 more
europepmc   +1 more source

Co-designing emergency communication for patients with mechanical circulatory support devices. [PDF]

JHLT Open
Fitzpatrick L, Mosely G, Davidson T, McLean J, Rix J, Wrigley C.   +5 more
europepmc   +1 more source

molIEreVIS: exploring and interpreting the evidence behind drug repurposing predictions. [PDF]

Front Bioinform
Alnouri A, Hinterreiter A, Steinparz C, Bajraktari L, Burgstaller-Muehlbacher S, Bauer M, Alanis-Lobato G, Streit M.   +7 more
europepmc   +1 more source

A Blended Case-Based and Practical Training Framework for Graduate Ultrasound Education: A Perspective on Competency-Based Instruction. [PDF]

Adv Med Educ Pract
Liu S, Zhu K, Ran Z, Zeng F, Zhu M, Wang Y, Wang D.   +6 more
europepmc   +1 more source

Striking a Balance With Business and Engineering Content in Biomedical Engineering Capstone Design. [PDF]

J Biomech Eng
Eberhardt AW.
europepmc   +1 more source