Results 51 to 60 of about 12,979,380 (326)

CPX‐351 in High‐Risk Relapsed Pediatric Acute Leukemia: Real‐World Phase 1 Data Establishing the FDA‐Approved Dose

open access: yesPediatric Blood &Cancer, EarlyView.
ABSTRACT Background/Objectives Outcomes for pediatric relapsed/refractory (R/R) acute myeloid leukemia (AML) remain dismal. CPX‐351, a liposomal formulation of cytarabine and daunorubicin, may have less off‐target toxicities than traditional chemotherapies and has shown improved outcomes for adults with newly diagnosed therapy‐related AML.
Jonathan D. Bender   +17 more
wiley   +1 more source

The Generality of Adult Development Stages and Transformations: Comparing Meaning-making and Logical Reasoning [PDF]

open access: yesIntegral Review, 2015
Human development theories differ in “context sensitivity,” covering those stressing development stages and those stressing continuously progressing changes.
Tom Hagström, Kristian Stålne
doaj  

Une biopolitique à bas bruit

open access: yesRecherches Sociologiques et Anthropologiques, 2019
This article analyses how, between the late 19th and early 20th centuries, the child and adolescent were understood via observation mechanisms which, in measuring bodies, had the goal of setting the standards of growth seen as “normal”, establishing ...
Nicoletta Diasio
doaj   +1 more source

The early stages of heart development: insights from chicken embryos [PDF]

open access: yes, 2016
The heart is the first functioning organ in the developing embryo and the detailed understanding of the molecular and cellular mechanisms involved in its formation provides insights into congenital malformations affecting its function and therefore the ...
Alsan   +19 more
core   +2 more sources

Pretreatment staging [PDF]

open access: yesCancer, 1976
Renewed emphasis on pretreatment staging of gynecologic malignancies has resulted from a number of reports on surgical staging of malignant cervical, endometrial, and ovarian lesions. These reports have shown that by pretreatment staging, in significant numbers of patients, more advanced disease was detectable than by the usual clinical methods.
J H, Nelson, R, Ureuyo
openaire   +2 more sources

Distinct stages in stress granule assembly and disassembly

open access: yeseLife, 2016
Stress granules are non-membrane bound RNA-protein (RNP) assemblies that form when translation initiation is limited and contain a biphasic structure with stable core structures surrounded by a less concentrated shell.
Joshua R. Wheeler   +4 more
semanticscholar   +1 more source

Improving the Evaluation and Management of Transfusion‐Related Iron Overload in Children, Adolescents, and Young Adults Following Cancer Treatment or Hematopoietic Stem Cell Transplantation

open access: yesPediatric Blood &Cancer, EarlyView.
ABSTRACT Background Transfusion‐related iron overload (TRIO) is a late effect of therapy impacting survivors of childhood cancer and hematopoietic stem cell transplantation (HSCT) who receive frequent packed red blood cell (pRBC) transfusions. Surprisingly, there are no accepted guidelines to assist providers in identifying and treating at‐risk ...
Luke Gingell   +3 more
wiley   +1 more source

Novel Genetic Risk Factor Identified for L‐Asparaginase‐Induced Pancreatitis in Pediatric Patients With Cancer

open access: yesPediatric Blood &Cancer, EarlyView.
ABSTRACT Background L‐asparaginase is a critical component in treatment protocols for pediatric acute lymphoblastic leukemia. Acute pancreatitis reactions can necessitate delays and, in some cases, discontinuation of L‐asparaginase, which compromises outcomes.
Edward J. Raack   +39 more
wiley   +1 more source

Outcomes and Surgical Management of Malignant Rhabdoid Tumor of the Kidney: A Report From the Pediatric Surgical Oncology Research Collaborative

open access: yesPediatric Blood &Cancer, EarlyView.
ABSTRACT Purpose Malignant rhabdoid tumor of the kidney (MRTK) is a rare, aggressive tumor seen in young children. The optimal timing of resection for locally advanced tumors is not well‐defined. The purpose of this study is to evaluate modern oncologic outcomes and the impact of surgical timing. Methods A multicenter retrospective review was performed
Hannah N. Rinehardt   +76 more
wiley   +1 more source

[Stages for Undertaking a Systematic Review].

open access: yesActa Médica Portuguesa, 2019
There has been an increase in the use of systematic review as a research methodology to compile and analyze large datasets of existing studies. With this increase, the recommendations to conduct this type of research also increased.
H. Donato, Mariana Donato
semanticscholar   +1 more source

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