Results 151 to 160 of about 111,717 (295)

Stagnation

open access: yes, 2009
Much work in geography and throughout the natural and social sciences in the last fifty years has been preoccupied with the notion of growth. The same is true of contemporary politics where the success or otherwise of governments has often been judged ...
Walmsley, Jim Dennis James
core  

Model‐Driven Monitoring and Parameter‐Based Development of an Escherichia coli Fed‐Batch Process for Production of a Fab Antibody Fragment Across Scales

open access: yesBiotechnology and Bioengineering, EarlyView.
ABSTRACT Maintaining consistent cellular physiology during bioprocess scale‐up or scale‐down is key to developing robust processes. However, the reliability of scale‐down bioreactor systems remains debated. Although the calibration of physiological parameters in mechanistic models across scales has been proposed as a scale‐down strategy, few studies ...
Fabian Schröder‐Kleeberg   +8 more
wiley   +1 more source

Mechanistic Analysis of Drug Linker Clearance During Ultrafiltration/Diafiltration of an Antibody–Drug Conjugate

open access: yesBiotechnology and Bioengineering, EarlyView.
ABSTRACT Ultrafiltration/diafiltration (UF/DF) is a key unit operation in the manufacture of antibody‐drug conjugates (ADCs), commonly utilized for post‐conjugation purification to remove residual Drug Linker (DL) compounds and affect buffer exchange.
Vasudev Tangry   +5 more
wiley   +1 more source

Induction Temperature and Feeding Profile Shape the Partitioning Between Soluble Product and Inclusion Body Formation in Escherichia coli

open access: yesBiotechnology and Bioengineering, EarlyView.
ABSTRACT Inclusion body (IB) processes yielding the recombinant product only as IBs are long‐established in the biopharmaceutical industry. Yet, for recombinant proteins that accumulate both IBs and soluble fraction depending on the selected upstream processing (USP) strategy, the influence of process parameters on the partitioning between both forms ...
Mohamed Elshazly   +7 more
wiley   +1 more source

Malthusian stagnation is efficient [PDF]

open access: yes, 2022
Cordoba, Juan Carlos, Liu, Xiying
core  

Goal Displacement and Goal Conflicts in Circular Innovation Initiatives: Types and Mitigation Practices

open access: yesBusiness Strategy and the Environment, EarlyView.
ABSTRACT Many firms set ambitious sustainability goals but these are frequently “displaced” by proxy goals that are easier to track and measure. However, the specific types of goal conflicts that follow from this displacement are poorly understood. We conducted a case study of circular innovation initiatives at a global MedTech company and identified ...
Wiebke Reim   +2 more
wiley   +1 more source

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