Results 71 to 80 of about 2,042,513 (399)

Function‐driven design of a surrogate interleukin‐2 receptor ligand

FEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang, Zelin Cheng, Teng Li, Fulian Wang, Liangminghui Zhang, Xiuxiu He, Lili Liu, Wei Wang, Aibin Liang, Guang Yang   +9 more
wiley   +1 more source

Pengaruh Kemampuan Penalaran Logika Matematika Terhadap Prestasi Belajar Mahasiswa Pendidikan Guru Madrasah Ibtidaiyah Di Stain Ponorogo [PDF]

, 2013
Kemampuan penalaran Logika Matematika sangat diperlukan dalam menerapkan aturan­aturan pemikiran yang tepat terhadap persoalan­persoalan konkrit yang dihadapi dalam kehidupan sehari­hari.
Hidayati, K. (Kurnia)
core   +2 more sources

Comparative Study of GeneXpert with ZN Stain and Culture in Samples of Suspected Pulmonary Tuberculosis.

Journal of clinical and diagnostic research : JCDR, 2016
INTRODUCTION Tuberculosis remains one of the deadliest communicable diseases. There are number of tests available for the diagnosis of tuberculosis but conventional microscopy has low sensitivity and culture although gold standard, but takes longer time ...
M. Agrawal, A. Bajaj, Vinaya Bhatia, S. Dutt   +3 more
semanticscholar   +1 more source

Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions

FEBS Letters, EarlyView.
Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf, Nicholas F. Downing, Kaitlyn M. Mills, Samuel C. Metcalfe, Alexander E. Kritzer, Lindsey D. Mayo, Peter C. Hollenhorst   +6 more
wiley   +1 more source

Microbiological Quality Check Containing Drugs Found Paracetamol In Some of Residences Américo Brasiliense / SP

Revista Brasileira Multidisciplinar - ReBraM /Brazilian Multidisciplinay Journal, 2011
It is known that a high microbial count can compromise the stability of medicines, thus reducing their therapeutic efficacy. This work tried to demonstrate that the microbial contamination can be directly related to the inadequate handling of the ...
Eliane Gandolpho Tótoli, Samaria Nascimento Stain   +1 more
doaj   +1 more source

Stain-free histopathology by programmable supercontinuum pulses

Nature Photonics, 2016
The preparation, staining, visualization and interpretation of histological images of tissue is well accepted as the gold standard process for the diagnosis of disease.
H. Tu, Y. Liu, D. Turchinovich, M. Marjanovic, J. Lyngsø, J. Lægsgaard, E. Chaney, Youbo Zhao, Sixian You, W. Wilson, Bingwei Xu, M. Dantus, S. Boppart   +12 more
semanticscholar   +1 more source

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

FEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva, Ariann E. Mendoza‐Martínez, P. Abril Medina‐Flores, Carlos Campero‐Basaldua, Alexander DeLuna, Soledad Funes   +5 more
wiley   +1 more source

Kontribusi Media dalam Memenuhi Kebutuhan Beragama Perempuan Pekerja Seks Komersial di Lokalisasi Lorong Indah

Fikrah: Jurnal Ilmu Aqidah dan Studi Keagamaan, 2018
Artikel ini bertujuan untuk mengungkap fenomena sosial dari prostitusi di Lorong Indah Pati. Sebagai manusia yang beragama, pekerja seks komersial (PSK) berhak mencari hidup bermakna.
Fatma Laili Khoirunnida, Zaimatus Sa'diyah, Irzum Farihah, Retno Retno   +3 more
doaj   +1 more source

Cell density–dependent nuclear‐cytoplasmic shuttling of SETDB1 integrates with Hippo signaling to regulate YAP1‐mediated transcription

FEBS Letters, EarlyView.
At low cell density, SETDB1 and YAP1 accumulate in the nucleus. As cell density increases, the Hippo pathway is gradually activated, and SETDB1 is associated with increased YAP1 phosphorylation. At high cell density, phosphorylated YAP1 is sequestered in the cytoplasm, while SETDB1 becomes polyubiquitinated and degraded by the ubiquitin–proteasome ...
Jaemin Eom, Jaewoong Jang, Jung Sun Park, Yong‐Kook Kang   +3 more
wiley   +1 more source