Results 231 to 240 of about 689,585 (301)

Bottom‐Up Programming of Cell States in Cancer Organoids with Defined Synthetic Adhesion Cues

Advanced Materials, EarlyView.
A bottom‐up biomaterial platform is developed to program transcriptomic states in pancreatic cancer organoids by tuning adhesion cues within synthetic matrices. By combining a Design of Experiments framework with multiobjective optimization, matrix compositions are identified that enrich specific cellular programs like EMT.
Ali Nadernezhad, Verena J. Kast, Dagmar Pette, Franziska Baenke, Daniel E. Stange, Carsten Werner, Daniela Loessner   +6 more
wiley   +1 more source

Patterned pre-sensory spontaneous activity drives the structural refinement of developing cochlear ribbon synapses. [PDF]

Front Synaptic Neurosci
Halim VC, Hallbrucker L, Ahrend JF, Setz C, Voorn RA, Franke S, Konrad V, Seiler A, Pangršič T, Roesler S, Vogl C.   +10 more
europepmc   +1 more source

Assembling a True “Olympic Gel” From over 16 000 Combinatorial DNA Rings

Advanced Materials, EarlyView.
Olympic gels are an elusive class of soft matter, consisting of molecular networks held together purely by mechanically interlocked rings. Their topological structure promises unique properties and functions, but their synthesis has proven notoriously difficult.
Sarah K. Speed, Yu‐Hsuan Peng, Azra Atabay, Krishna Gupta, Toni Müller, Carolin Fischer, Ilka M. Hermes, Jens‐Uwe Sommer, Michael Lang, Elisha Krieg   +9 more
wiley   +1 more source

Viral Infection‐Inspired Autonomous Detection of Fusion‐Competent Viruses for Screening and Environmental Surveillance

Advanced Materials, EarlyView.
Inspired by viral entry mechanisms, the FUSION assay enables autonomous detection of respiratory viruses via membrane fusion–triggered CRISPR‐Cas13a activation. VEACON selectively fuses with fusion‐competent viruses, triggering fluorescence within confined vesicles.
Jae Chul Park, Yidam Song, Hyun‐Woo Choi, Jaeuk Sung, Harin Jin, WonSeok Gwak, Kirim Yoo, Soohwang Lee, Jongeon Park, Jeongmin Kim, Hye‐Jun Jo, Jahyun Koo, Youngdo Jeong, Kwan Hyi Lee, Seung‐Jung Kee, Hojun Kim   +15 more
wiley   +1 more source

Development of a Novel IHC Assay for PD-L1 Detection in Non-Small Cell Lung Cancer. [PDF]

Biomedicines
Willett F, MacLennan M, Khelifa S, Vennapusa B, Gautrey H, Parkin M, Wilson KR, O'Toole K, Dayal S, Chiweshe J, Monroe R, Lian F.   +11 more
europepmc   +1 more source

Lytic IFNγ is stored in cytotoxic granules and coreleased with granzyme B to mediate cytotoxic T lymphocyte killing. [PDF]

Cell Mol Immunol
Li X, Schirra C, Wirkner ML, Tu SM, Lin CH, Hohmann M, Gu Y, Santiago L, Pardo J, Arretxe I, Alawar N, Chouaib AA, Becherer U, Lee PH, Hsu HJ, Laschke MW, Baldari CT, Dustin ML, Rettig J, Krause E, Chang HF.   +20 more
europepmc   +1 more source

Biological Performance of Modified Glass Ionomer Cement: Antibacterial Activity, Cytocompatibility, and Rabbit Pulpal Response. [PDF]

Int Dent J
Dejyong K, Indoung S, Sornying P, Manmoo S, Rotpenpian N.   +4 more
europepmc   +1 more source

VPS13A Deficiency Leads to Impaired Lipid Distribution and Alteration of Mitochondrial Calcium Homeostasis in Fibroblasts of VPS13A Disease Patients. [PDF]

Mov Disord
Grossmann D, Spranger A, Fischer E, Schubarth JW, Leopold J, Glaß H, Klicker S, Thi MUD, Bartalis AE, Hermann A, Peikert K.   +10 more
europepmc   +1 more source