Results 221 to 230 of about 3,474,741 (402)

Genomics‐led approach to drug testing in models of undifferentiated pleomorphic sarcoma

Molecular Oncology, EarlyView.
GA text Genomic data from undifferentiated pleomorphic sarcoma patients and preclinical models were used to inform a targeted drug screen. Selected compounds were tested in 2D and 3D cultures of UPS cell lines. A combination of trametinib and infigratinib was synergistic in the majority of UPS cell lines tested, which was further confirmed in an ex ...
Piotr J. Manasterski, Molly R. Danks, John P. Thomson, Morwenna Muir, Martin Lee, John C. Dawson, Ana T. Amaral, Juan Diaz‐Martin, David S. Moura, Javier Martin‐Broto, Ali Alsaadi, Donald M. Salter, Ailsa J. Oswald, Graeme Grimes, Larry Hayward, Ted R. Hupp, Karen Sisley, Paul H. Huang, Neil O. Carragher, Valerie G. Brunton   +19 more
wiley   +1 more source

Dihydrotestosterone and 17β-estradiol modulate TMJ osteoarthritis development and reveal sex-specific differences in pathogenesis. [PDF]

Sci Rep
Tomura T, Ishii T, Kasahara N, Nishii Y.
europepmc   +1 more source

ON A NEW METHOD FOR FACILITATING THE STAINING OF MICROSCOPICALLY SMALL OBJECTS [PDF]

, 1903
V. H. Blackman
openalex   +1 more source

Ratiometric analysis of Acridine Orange staining in the study of acidic organelles and autophagy

Journal of Cell Science, 2016
M. Thomé, E. Filippi-Chiela, E. Villodre, C. Migliavaca, G. Onzi, K. Felipe, G. Lenz   +6 more
semanticscholar   +1 more source

The subcellular distribution of phosphorylated Y‐box‐binding protein‐1 at S102 in colorectal cancer patients, stratified by KRAS mutational status and clinicopathological features

Molecular Oncology, EarlyView.
This study identifies nuclear YB‐1 S102 phosphorylation as a marker associated with KRAS and FBXW7 mutations in colorectal cancer. Mutated KRAS correlates specifically with nuclear, not cytoplasmic, S102 YB‐1. These findings provide the first ex vivo evidence of this link in CRC and suggest future studies should assess the prognostic and therapeutic ...
Konstanze Lettau, Stephan Forchhammer, Birgit Fehrenbacher, Lejla Mahmutovic, Marcus Scharpf, Gunnar Blumenstock, Martin Schaller, Irina Bonzheim, Shayan Khozooei, Mahmoud Toulany   +9 more
wiley   +1 more source

Correction: MiR-137 promotes TLR4/NF-κB pathway activity through targeting KDM4 A, inhibits osteogenic diferentiation of human bone marrow mesenchymal stem cells and aggravates osteoporosis. [PDF]

J Orthop Surg Res
Yu YF, Yao PQ, Wang ZK, Xie WW.
europepmc   +1 more source

A New Process of Preparing and Staining Fresh Brain for Microscopic Examination [PDF]

, 1876
Bevan Lewis
openalex   +1 more source

Therapeutic applications of a novel humanized monoclonal antibody targeting chemokine receptor CCR9 in pancreatic cancer

Molecular Oncology, EarlyView.
C–C chemokine receptor type 9 (CCR9) is an immune checkpoint in pancreatic ductal adenocarcinoma (PDAC). Novel anti‐CCR9 antibody SRB2 was evaluated in combination with cytotoxic chemotherapy in PDAC cells, patient‐derived organoids, patient‐derived xenografts, and humanized mouse models.
Hannah G. McDonald, Anna M. Reagan, Charles J. Bailey, Mei Gao, Muqiang Gao, Angelica L. Solomon, Michael J. Cavnar, Prakash K. Pandalai, Mautin T. Barry‐Hundeyin, Megan M. Harper, Justin A. Rueckert, Ángela Turrero, Araceli Tobio, Anxo Vidal, Daniel Roca‐Lema, Elia Álvarez‐Coiradas, Pablo Garrido, Laureano Simón, Joseph Kim   +18 more
wiley   +1 more source

New Approaches Based on Serial-Block Face Electron Microscopy to Investigate the Peripheral Nervous System. [PDF]

J Peripher Nerv Syst
Borisovs V, Bossi M, Matino L, Marmiroli P, Cavaletti G.   +4 more
europepmc   +1 more source

A NEW STAINING TECHNIQUE FOR POLAR BODIES [PDF]

, 1950
M. Wachstein, Marina Pisano
openalex   +1 more source