Results 51 to 60 of about 54,377 (222)

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Integration of transcriptome and metabolome analyses reveals key lodging-resistance-related genes and metabolic pathways in maize

Frontiers in Genetics, 2022
Stalk lodging, or breakage of the stalk at or below the ear, is one of the vital factors causing substantial yield losses in maize (Zea mays. L). Lodging affects maize plants’ physiological and molecular processes, eventually impacting plant growth and ...
Lei Liu, Songtao Liu, Haibo Lu, Zaimin Tian, Haichao Zhao, Dong Wei, Shuo Wang, Zhihong Huang   +7 more
doaj   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

A Review on Overcoming Dual Challenges for Maize Cropping under High Plant Density: Stalk Lodging and Kernel Abortion [PDF]

, 2022
Increased optimal plant density is necessary in ensuring future food security by increasing crop productivity. However, maintaining relatively high plant density has to overcome two challenges i.e. kernel abortion and stalk lodging. The response of maize
Khan, Shahbaz, Nazeer, Wajid, Iqbal, Javed, Nadeem, Muhammad, Sher, Alam, Faiz, Sajid, Maqbool, Muhammad Mudassar   +6 more
core   +2 more sources

Genome-wide association study identifies novel candidate loci or genes affecting stalk strength in maize

Crop Journal, 2023
Stalk strength increases resistance to stalk lodging, which causes maize (Zea mays L.) production losses worldwide. The genetic mechanisms regulating stalk strength remain unclear.
Shuhui Xu, Xiao Tang, Xiaomin Zhang, Houmiao Wang, Weidong Ji, Chenwu Xu, Zefeng Yang, Pengcheng Li   +7 more
doaj   +1 more source

Women of AHLAF: Focus on Diversity, Equity, and Inclusion

, 2021
Lodging Magazine sat down with American Hotel & Lodging Association Foundation Diversity & Inclusion Committee members to learn more about their passion, focus, and goals surrounding the task force.
Lodging Magazine
core  

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

Molecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang, Hyung Seok Kim, Geum Ok Baek, Moon Gyeong Yoon, Su In Lee, Jee‐Yeong Jeong, Ji Eun Han, Soon Sun Kim, Jae Youn Cheong, Jung Woo Eun   +9 more
wiley   +1 more source

Assigning sex to pre-adult stalk-eyed flies using genital disc morphology and X chromosome zygosity [PDF]

, 2006
Background: In stalk-eyed flies ( Diopsidae) the eyes and antennae are laterally displaced at the ends of elongated eyestalks. Eyespan and the degree of sexual dimorphism in eyespan vary considerably between species and several sexually dimorphic species
Fowler, K., Andrew Pomiankowski, Smith, H., Pomiankowski, Andrew, Pomiankowski, A., Martin Carr, Samuel Cotton, Fowler, Kevin, Kevin Fowler, Carr, Martin, Hazel Smith, David W Rogers, Cotton, S., Rogers, D.W., Smith, Hazel, Carr, M., Cotton, Samuel, Rogers, David W.   +17 more
core   +1 more source

Pathways and pitfalls: a qualitative study of student experiences in biomedical science education

FEBS Open Bio, EarlyView.
Biomedical science students from underrepresented backgrounds face barriers including financial strain, disrupted laboratory access and cultural exclusion. Peer networks provide vital support when institutional systems are difficult to navigate. To create inclusive learning environments and achieve academic success, educators should blend active, hands‐
Olivia J. Russell, Cassy Ross, Panagiota S. Filippou, Bruno Silvester Lopes, Dominic Gilchrist, Paul Dean, Kamar Ameen‐Ali, Tora K. Smulders‐Srinivasan, Ahmad A. Khundakar   +8 more
wiley   +1 more source

A Review on Ov view on Overcoming Dual Challenges for Maiz coming Dual Challenges for Maize Cropping under High Plant Density: Stalk Lodging and Kernel Abortion

Journal of Bioresource Management, 2022
Increased optimal plant density is necessary in ensuring future food security by increasing crop productivity. However, maintaining relatively high plant density has to overcome two challenges i.e. kernel abortion and stalk lodging.
Alam Sher , Javed Iqbal , Wajid Nazeer , Muhammad Mudassar Maqbool, Muhammad Nadeem   +4 more
doaj