IDENTIFYING PHYSIOLOGICAL, MORPHOLOGICAL, AND GENETIC DRIVERS OF KEY INTERMEDIARY PHENOTYPIC TRAITS ASSOCIATED WITH STALK LODGING RESISTANCE WITHIN GENETICALLY DIVERSE MAIZE GERMPLASM AND SORGHUM [PDF]
Maize stalk lodging reduces grain yields due to the permanent breakage or deformation of stalk tissue before grain harvest. To reveal new insights into the complex problem of maize stalk lodging, this dissertation will examine three primary objectives ...
Bokros, Norbert
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Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
Dissection of the genetic architecture of stalk mechanical strength and in vivo haploid induction in maize [PDF]
, 2016 Stalk lodging causes yield losses in maize cultivation ranging from 5 to 20% annually worldwide and stalk mechanical strength is widely accepted as an indirect indicator for its measurement.
Hu, Haixiao
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Changes of Weight and in-Kernel Content Values of Maize Hybrids (Occitan, Colomba, DK-471) as a Result of Damaging dy European Corn Borer. Kukorica hibridek (Occitan, Colomba, DK-471) súly- és beltartalmi érték változása a kukoricamoly (Ostrinia nubilalis Hbn.) károsítása következtében. [PDF]
, 2002 ÖSSZEFOGLALÁS Vizsgálatunkat 2001-ben két tábla három különböző hibriddel elvetett állományában vizsgáltuk véletlenszerű mintaterek kijelölésével. Első felmérésünket egy 120 ha-os COLOMBA és OCCITAN, míg a második vizsgálatunkat egy 50 ha-os DK-471-es
Keszthelyi, Sándor, Takács, András
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Molecular Oncology, EarlyView.Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat +8 more
wiley +1 more source
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Genotypic variation in sorghum [Sorghum bicolor (L.) Moench] exotic germplasm collections for drought and disease tolerance [PDF]
, 2013 Citation: Kapanigowda, M., . . . & Little, C. (2013). Genotypic variation in sorghum [Sorghum bicolor (L.) Moench] exotic germplasm collections for drought and disease tolerance. SpringerPlus, 2, 650.
Aiken, Robert M. +6 more
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Genetic mapping and genomic selection for maize stalk strength
BMC Plant Biology, 2020 Background Maize is one of the most important staple crops and is widely grown throughout the world. Stalk lodging can cause enormous yield losses in maize production.
Xiaogang Liu +6 more
doaj +1 more source