Results 31 to 40 of about 34,044 (262)

Computational research on the formation mechanism of double humps in pump–turbines

Engineering Applications of Computational Fluid Mechanics, 2021
The hump formation mechanism has not been fully understood so far, mainly because of two difficulties in analysis. The first one is how to find the most important external characteristic factor inducing humps, and the other is how to avoid too many ...
Yong Liu, Dezhong Wang, Hongjuan Ran
doaj   +1 more source

Translating whole‐genome doubling into precision medicine in cancer

Molecular Oncology, EarlyView.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source

CFD-Based In-Depth Investigation of the Effects of the Shape and Layout of a Vortex Generator on the Aerodynamic Performance of a Multi-MW Wind Turbine

Applied Sciences, 2021
Thick airfoils are conventionally adopted in the blade root region of a wind turbine to ensure structural safety under extreme conditions, despite the resulting power loss.
Hyeon-Gi Moon, Sunho Park, Kwangtae Ha, Jae-Ho Jeong   +3 more
doaj   +1 more source

PANoptosis in the pathogenesis of myelodysplastic syndromes

Molecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla, Jyoti Lamichhane, Cameron Lewis, Peter Breslin, Jiwang Zhang   +4 more
wiley   +1 more source

ATZ‐1 promotes DNA replication efficiency to maintain normal meiotic function

FEBS Open Bio, EarlyView.
Absence of ATZ‐1 interferes with meiotic DNA replication and cell cycle function via CHK‐1. This causes downstream defects associated with DNA damage and genomic integrity. Taken together, this study suggests that ATZ‐1 influences DNA replication efficiency and cell cycle function to maintain normal meiotic function.
Taylin E. Gourley, Luke W. Molesworth, Nethma H. Waduge, Fahimeh Eskandari, Peter R. Boag, Gregory M. Davis   +5 more
wiley   +1 more source

Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level

Aging and Cancer, EarlyView.
This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley   +1 more source

Experimental study of the aerodynamics of micro airfoils with wavy surface and the use of different patterns inspired by nature [PDF]

فناوری در مهندسی هوافضا
Enhancing the aerodynamic performance of airfoils, minimizing drag, and controlling flow separation are key objectives in aerospace research, pursued through various methods.
Mehdi Abedi, Ramin Zakeri
doaj   +1 more source

Identification and Modeling Method of Longitudinal Stall Aerodynamic Parameters of Civil Aircraft Based on Improved Kirchhoff Stall Aerodynamic Model

Aerospace, 2023
The stall aerodynamic model based on Kirchhoff’s theory of flow separation is widely used in the identification and modeling of stall aerodynamic parameters. However, it has two defects.
Lixin Wang, Rong Zhao, Ke Xu, Yi Zhang, Ting Yue   +4 more
doaj   +1 more source

Creating Ti–Fe α/β Alloys by Diffusion‐Driven Solid‐State Processing

Advanced Engineering Materials, EarlyView.
This study proposes making alloys containing fast diffusing elements that are difficult to produce by ingot metallurgy, by diffusion‐driven solid‐state HIP processing of elemental powders and low‐temperature homogenisation. Here, novel Fe‐Ti α–β alloys are formed having fine α–β lamellae, a small β prior grain size without significant intermetallics ...
Jiaqi Xu, Xun Zhang, Jack M. Donoghue, Albert D. Smith, Rahul Unnikrishnan, Rhys Thomas, Vahid Nekouie, Jie Luo, Dongchen Hu, Michael Preuss, Philip J. Withers   +10 more
wiley   +1 more source

A stalled fork stalls recombination

The Journal of Cell Biology, 2005
Homologous recombination does not rescue stalled replication forks during S phase, report Meister et al. on page 537. Rather they find that replication and recombination are separated in terms of when and where they occur. If inappropriate recombination does occur when replication is stalled, replication forks fall apart.Researchers have debated ...
openaire   +2 more sources