Results 31 to 40 of about 73,280 (245)
Investigating the CREDIT History of Supernova Remnants as Cosmic-Ray Sources
The Astrophysical Journal LettersSupernova remnants (SNRs) have long been suspected to be the primary sources of Galactic cosmic rays. Over the past decades, great strides have been made in the modeling of particle acceleration, magnetic field amplification, and escape from SNRs.
Anton Stall +2 more
doaj +1 more source
Journal of Fluid Science and Technology, 2014 The effect of 3-dimensional blade on the turbine characteristics has been investigated experimentally by model testing under steady flow conditions and simulated numerically by quasi-steady analysis under sinusoidal flow conditions, in order to improve ...
Manabu TAKAO +3 more
doaj +1 more source
Computational research on the formation mechanism of double humps in pump–turbines
Engineering Applications of Computational Fluid Mechanics, 2021 The hump formation mechanism has not been fully understood so far, mainly because of two difficulties in analysis. The first one is how to find the most important external characteristic factor inducing humps, and the other is how to avoid too many ...
Yong Liu, Dezhong Wang, Hongjuan Ran
doaj +1 more source
RNA‐related functions of BRCA2 in transcription, replication, and genome stability
FEBS Letters, EarlyView.Beyond its role in homologous recombination, BRCA2 regulates R‐loop homeostasis, DNA–RNA hybrid resolution, RNA polymerase II dynamics, and transcriptional activation. Disruption of any of these functions can contribute to genome instability, inflammatory signaling, and tumorigenesis. BRCA2 is a central tumor suppressor protein best known for its roles
Lucia Alvaro‐Aranda +2 more
wiley +1 more source
Applied Sciences, 2021 Thick airfoils are conventionally adopted in the blade root region of a wind turbine to ensure structural safety under extreme conditions, despite the resulting power loss.
Hyeon-Gi Moon +3 more
doaj +1 more source
A context‐dependent modulatory role for eIF6 in acquired resistance to vemurafenib in melanoma
FEBS Letters, EarlyView.Acquired resistance to vemurafenib upregulates the translation factor eIF6 in melanoma cells. Silencing eIF6 in resistant cells reduces proliferation and partially restores drug sensitivity, whereas its overexpression increases sensitivity across melanoma lines regardless of BRAF status, via modulation of mTOR, S6K, and MAPK signaling.
George Kyriakopoulos +9 more
wiley +1 more source
Aerospace, 2023 The stall aerodynamic model based on Kirchhoff’s theory of flow separation is widely used in the identification and modeling of stall aerodynamic parameters. However, it has two defects.
Lixin Wang +4 more
doaj +1 more source
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
PANoptosis in the pathogenesis of myelodysplastic syndromes
Molecular Oncology, EarlyView.PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla +4 more
wiley +1 more source
Experimental study of the aerodynamics of micro airfoils with wavy surface and the use of different patterns inspired by nature [PDF]
فناوری در مهندسی هوافضاEnhancing the aerodynamic performance of airfoils, minimizing drag, and controlling flow separation are key objectives in aerospace research, pursued through various methods.
Mehdi Abedi, Ramin Zakeri
doaj +1 more source