Results 81 to 90 of about 59,594 (307)
Advanced Science, EarlyView.This study identifies the HDAC6/GATA4/HtrA1 axis as a critical driver of cellular senescence in the inner ear. GATA4 nuclear translocation, facilitated by HDAC6 downregulation, transcriptionally activates HtrA1, promoting hair cell senescence, SASP, and audio‐vestibular dysfunction in models of Ménière's disease and age‐related audio‐vestibular ...
Na Zhang +16 more
wiley +1 more source
Targeting the PDK1/c‐Myc/SOX10 Signaling in Oligodendrocytes Alleviates Neuropathic Pain
Advanced Science, EarlyView.This work reveals that oligodendrocyte homeostasis, mediated by PDK1, is a critical determinant of neuropathic pain (NPP) pathogenesis. Disruption of PDK1 in oligodendrocytes impairs SOX10‐dependent myelination programs through c‐Myc accumulation, leading to disrupted myelination and the pathophysiology of NPP.
Pingping Qiao +7 more
wiley +1 more source
The effect of leading edge serrations on dynamic stall
, 2012 An investigation into the effects of dynamic stall was carried out on six aerofoil profiles with sinusoidal leading edges having two amplitudes and three different wavelengths.
Borg, Jonathan
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UCHL3 Regulates Subgenomic Flaviviral RNA Condensates to Promote Virus Propagation
Advanced Science, EarlyView.ABSTRACT Flavivirus subgenomic RNAs (sfRNAs) antagonise antiviral defences, yet how sfRNAs are organized and maintained in cells remains poorly understood. Here we identify ubiquitin C‐terminal hydrolase L3 (UCHL3) as a post‐translational regulator of flavivirus sfRNA stability and function.
Oscar Trejo‐Cerro +7 more
wiley +1 more source
Leading-Edge Roughness Affecting Diamond-Wing Aerodynamic Characteristics
Aerospace, 2018 Diamond wing configurations for low signature vehicles have been studied in recent years. Yet, despite numerous research on highly swept, sharp edged wings, little research on aerodynamics of semi-slender wings with blunt leading-edges exists. This paper
Andrei Buzica +3 more
doaj +1 more source
Bifurcation analysis of surge and rotating stall in the Moore-Greitzer compression system
, 2002 A simple compression system model, described by a set of three ordinary nonlinear differential equations (the Moore-Greitzer model) is studied using bifurcation analysis to give a qualitative understanding of the presence of surge and rotating stall ...
Kullmann, L, Champneys, AR, Hos, C
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DNA Replication Errors Drive Genome‐Wide Small Inverted Triplication Dynamics
Advanced Science, EarlyView.This study provides insight into the dynamic equilibrium mechanism of a novel structural variant, small inverted triplication (SIT), which is generated by misalignment of the 3’ flap generated under DNA replication stress with palindromic sequence. Alternatively, the end sequence may fold back on itself to form an inverted fragment.
Yi Lei +12 more
wiley +1 more source
Analysis and Prediction of the Stability Limit for Centrifugal Compressors with Vaneless Diffusers
International Journal of Turbomachinery, Propulsion and PowerA numerical study was conducted to identify the mechanisms involved in the destabilisation of centrifugal compressors with vaneless diffusers. A stability analysis—carried out on the rotating and fixed parts of the studied machines—showed that the ...
Xavier Flete +5 more
doaj +1 more source
Advanced Science, EarlyView.STAU2 undergoes phase separation to form dynamic condensates that package target mRNAs and deliver them to the distal ends of growing neuronal dendrites. STAU2 condensates stabilize embedded mRNAs and repress their translation. Synaptic activity bidirectionally remodels STAU2 condensates, coordinating local translation of STAU2‐associated mRNAs ...
Shijing Huang +8 more
wiley +1 more source
On the effects of leading edge vortex generators on an OA209 airfoil
, 2009 Leading edge vortex generators have been found to significantly increase the aerodynamic performance of an airfoil under dynamic stall conditions. However, the principle of operation of these devices is still unclear.
Gardner, Anthony +3 more
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