Results 221 to 230 of about 28,185 (297)

Novel drugs approved by the EMA, the FDA and the MHRA in 2025: A year in review

British Journal of Pharmacology, EarlyView.
Abstract In the 2025 novel drug mini‐review, one can take a full measure of the ingenuity that underlies current drug design and development, despite the year's smaller harvest (46 novel drugs) compared to 2024 (53) and 2023 (70). 54% of the novel drugs are first‐in‐class (FIC).
Andreas Papapetropoulos, Stavros Topouzis, Steve P. H. Alexander, Miriam M. Cortese‐Krott, Zsuzsanna Helyes, Kirill Martemyanov, Claudio Mauro, Nithyanandan Nagercoil, Reynold A. Panettieri Jr, Hemal H. Patel, Rainer Schulz, Barbara Stefanska, Gary J. Stephens, Nathalie Vergnolle, Xin Wang, Stephen Ward, Péter Ferdinandy   +16 more
wiley   +1 more source

Advancing conservation breeding programs for marine invertebrates

Conservation Biology, EarlyView.
Abstract In the face of ecosystem change and biodiversity loss caused by climate change and other stressors, conservation breeding, or captive breeding, with the aim of reintroduction for wild population recovery, is an emerging tool for preventing species’ extinction and rehabilitating ecosystems.
Elora H. López‐Nandam, Bart Shepherd, Kylie Lev, Rebecca Albright   +3 more
wiley   +1 more source

Enhanced pure pursuit with dynamic steering control for autonomous mobile robots and application to safe navigation in chemical plants. [PDF]

Sci Rep
Promkaew N, Junhuathon N, Phuphaphud A, Kulvanit P, Sukpancharoen S.   +4 more
europepmc   +1 more source

PHGDH Orchestrates Cell Cycle Progression to Drive Cardiomyocyte Proliferation and Myocardial Regeneration via TGF‐β/Smad Signalling Pathway

Cell Proliferation, EarlyView.
PHGDH promoted cardiomyocyte proliferation and myocardial regeneration via cell cycle and TGF‐β/Smad signalling pathways during cardiac repair. Moreover, PHGDH benefits cardiac repair and cardiomyocyte proliferation in mammalian mice following MI. ABSTRACT The mature mammalian heart has limited ability for self‐repair and regeneration.
Han Zhang, Li Zhang, Zehao Feng, Xing Li, Zhaohui Qiu, Xingyun Wang, Lingmei Qian   +6 more
wiley   +1 more source

The optimization method of wing plasma ice shape regulation based on quantitative assessment of flight risk. [PDF]

Sci Rep
Li Z, Dou P, Huang Q.
europepmc   +1 more source

Three-dimensional design, simulation and optimization of a centrifugal compressor impeller with double-splitter blades. [PDF]

Heliyon
Tasharrofi M, Heidarian Shahri M, Madadi A.   +2 more
europepmc   +1 more source

Cold‐blooded commerce: Characterizing and predicting trade in Australian squamates

Conservation Science and Practice, EarlyView.
Despite a national ban on native wildlife exports, Australian reptile species continue to appear in international trade. Using boosted regression trees, we found that large body sizes and taxonomic family, rather than color or patterning, best predicted trade presence. We identified 59 species likely to be targeted in the future, providing key insights
Sebastian Chekunov, Rodolfo O. Anderson, Thomas A. A. Prowse, John Measey, Adam Toomes, Phillip Cassey   +5 more
wiley   +1 more source

Unfixing Place: Time and Value in the Anthropology of Food

Culture, Agriculture, Food and Environment, EarlyView.
ABSTRACT Although many anthropologists have engaged with the political and economic work of “place” in qualifying and working with food, time has rarely featured substantively in the economic and political life of the comestible. Gathering themes from my ethnographic research in Northern Italy and excavation time in anthropological scholarship on food,
Janita Van Dyk
wiley   +1 more source

Fall experiences of ambulatory children and adults with cerebral palsy: A qualitative study using thematic content analysis

Developmental Medicine &Child Neurology, EarlyView.
Abstract Aim To qualitatively assess the causes, adaptations, and psychosocial impact of falls, and solutions for safer environments, as shared by individuals diagnosed with cerebral palsy (CP). Method Ambulatory adults with CP (n = 165; age median [interquartile range], range: 30 years [25–50], 18–76 years); 101 females, 59 males, five non‐binary/not ...
Marissa Esterley, Linda E. Krach, Kari Pederson, Sandy Callen Tierney, Nathan G. Wandersee, Elizabeth R. Boyer, on behalf of The Cerebral Palsy Research Network   +6 more
wiley   +1 more source

Gemini: the first underground testbed for seismic isolation and inter-platform control in next-generation gravitational-wave detectors. [PDF]

Eur Phys J Plus
Andric T, Harms J, Caravella I, Angiolilli M, Cortis D, D'Ambrosio N, De Deo M, D'Incecco M, Di Ludovico A, Gerberding O, Lalli A, Lantz B, Leonzi L, Macolino C, Mittleman R, Mow-Lowry C, Orlandi D, Pirro S, Ricci M, Rollins J, Warner J.   +20 more
europepmc   +1 more source