Results 211 to 220 of about 2,940,165 (241)

Walkbot-Based Robot-Assisted Gait Training and Phase-Specific Lower-Limb Torque in Parkinson's Disease: A Retrospective Comparative Study. [PDF]

Brain Sci
Ozkocak G, Calabrò RS.
europepmc   +1 more source

SPHINX31 acts as a SRPK1 inhibitor targeting the ATR/DNA‐PKcs/CHK1 replicative checkpoint to inhibit cell growth in non‐small cell lung cancer

Molecular Oncology, EarlyView.
The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim, Aurelie Genoux, Nadiia Zubchuk, Haoyang Zheng, Perla Salameh, Theo Ziegelmeyer, Fabien Dalonneau, Margot Rouchette, Christiane Oddou, Simona Miron, Helene Polveche, Adiilah Mamode Cassim, Carmen Garrido, Eleni Nikolakaki, Didier Auboeuf, Tao Jia, Sophie Zinn‐Justin, Beatrice Eymin   +17 more
wiley   +1 more source

The Role of Ecological and Complex Gait and Postural Tasks in the Assessment of Subtle Deficits in Parkinson's Disease. [PDF]

Healthcare (Basel)
Manzari P, Orejel Bustos AS, Rossi A, Vannozzi G, Buzzi MG, Belluscio V.   +5 more
europepmc   +1 more source

Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation

Molecular Oncology, EarlyView.
How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim, Alvin Kunyao Guo, Yoko Itahana, Srinivasaraghavan Kannan, Valerie Goh, Mingmin Ong, Terina Yan Wen Tay, Weiying Ye, Sabhashina Radha Krishnan, Jun Nishiyama, Chandra S Verma, Koji Itahana   +11 more
wiley   +1 more source

Inertial measurement unit-based characterization of gait patterns in Asian elephants: clinically sound elephants and elephants with gait abnormalities. [PDF]

Front Vet Sci
Khammesri S, Wantanajittikul K, Namwongprom K, Kittisirikul N, Thitaram C, Thitaram N, Brown JL, Kongsawasdi S.   +7 more
europepmc   +1 more source

Targeting the EpCAM‐AXL axis to overcome drug resistance in lung cancer

Molecular Oncology, EarlyView.
Lung cancer cells often evade therapy by hijacking signaling pathways. We reveal that cleaved EpCAM (sEpCAM) stabilizes the oncogenic protein AXL, driving NF‐κB and STAT3‐mediated chemoresistance. This EpCAM‐AXL axis identifies a high‐risk patient subset with poor prognosis.
Alexa Guerrero‐Alba, Mark Shacker, Timothy P. Fleming, Michael A. Smith, Ross M. Bremner, Narendra V. Sankpal   +5 more
wiley   +1 more source

Assessment of IMU-derived lower-limb kinematics in transtibial amputees: A practical and accessible clinical workflow. [PDF]

PLoS One
Rattanakoch J, Limroongreungrat W, Guerra G, Manupibul U, Apidech H, Niamsang W, Suphab M, Laucha T, Samala M.   +8 more
europepmc   +1 more source

Acute Effects of High-Speed Repetitive Loading on Achilles Tendon Viscoelasticity and Ankle Agonist-Antagonist Co-Contraction: A Combined MyotonPRO and Surface Electromyography Analysis in Male Collegiate American Football Players. [PDF]

J Funct Morphol Kinesiol
Kang S, Lee JY, Jeong JH, Lee CK, Park I.   +4 more
europepmc   +1 more source

Framing the crisis: X/Twitter discourse on Ukrainian war refugees in Poland. [PDF]

PLoS One
Piróg T, Olszowski R, Pięta P, Masłyk T.   +3 more
europepmc   +1 more source

Functional Biomechanical Tests of the Foot and Ankle in Physiotherapy and Sports-Outcome Measures, Wearable Sensor Integration, and Psychometric Properties: A Systematic Review. [PDF]

J Clin Med
Semjonova G, Vallejo-Martínez R, Ceballos-Laita L, Jiménez-Del-Barrio S, Davidovics S, Davidovica A.   +5 more
europepmc   +1 more source