Digital twins to accelerate target identification and drug development for immune‐mediated disorders
FEBS Open Bio, EarlyView.Digital twins integrate patient‐derived molecular and clinical data into personalised computational models that simulate disease mechanisms. They enable rapid identification and validation of therapeutic targets, prediction of drug responses, and prioritisation of candidate interventions.
Anna Niarakis, Philippe Moingeon
wiley +1 more source
Diagnostic accuracy of the Timed Up and Go and Five Times Sit-to-Stand tests for fall risk screening in community-dwelling older adults in northern Thailand: a retrospective study. [PDF]
PeerJKhieorawong T, Srithawong A.
europepmc +1 more source
Rapid screening of staphylokinase protein variants using an unpurified cell‐free expression system
FEBS Open Bio, EarlyView.An unpurified cell‐free protein synthesis (CFPS) platform enables rapid functional screening of staphylokinase variants. Direct plasminogen‐activation assays performed in microplate format provide real‐time activity readouts, allowing rapid identification and ranking of variants with improved or reduced fibrinolytic activity without protein ...
Maria Tomková +3 more
wiley +1 more source
Nutrient resorption rather than root acquisition offsets increased N limitation induced by the stand development of a secondary Pinus tabuliformis forest in North China. [PDF]
BMC Plant BiolDuan S +6 more
europepmc +1 more source
FEBS Open Bio, EarlyView.5‐Aminolevulinic acid combined with ferric ammonium citrate (5‐ALA/FAC) stimulates dermal papilla cell activity and promotes hair follicle growth. The treatment enhances ERK and AKT signaling, increases hair‐inductive gene expression, and restores dermal papilla function suppressed by dihydrotestosterone and oxidative stress, resulting in enhanced hair
Han‐Wook Ryu, Eok‐Soo Oh, Sewoon Kim
wiley +1 more source
A climate- and stage-sensitive stand growth and yield model of natural <i>Larix gmelinii</i> forests in northeast China. [PDF]
Front Plant SciDong L, Mei X, Liu Z.
europepmc +1 more source
Stand-up in the age of outrage
Abstract: In the context of an expanding societal awareness of social injustice, and inequality, stand-up comedy is frequently caught in the crosshairs of discourses on free speech and political correctness. This study examines the evolving relationship between comedic critique and contemporary discourses on the boundaries of humour.
Nicolaï, Jonas, Maeseele, Pieter
openaire +1 more source
Systemic dysregulation of apolipoproteins in amyotrophic lateral sclerosis serum
FEBS Open Bio, EarlyView.Amyotrophic lateral sclerosis (ALS) is a fatal disease that damages motor neurons. This study found that people with ALS show significant changes in blood fats and the proteins that carry them. Several apolipoproteins were higher, lipid balances were altered, and normal protein–lipid relationships were disrupted.
Finula I. Isik +6 more
wiley +1 more source
Distribution characteristics and influencing factors of carbon storage in <i>Populus</i> plantations with different stand ages in the Luxi Yellow River floodplain, China. [PDF]
Front Plant SciWang Z +8 more
europepmc +1 more source
FEBS Open Bio, EarlyView.Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane +11 more
wiley +1 more source