Results 141 to 150 of about 899,016 (306)
The Siren Song of History: Originalism and the Religion Clauses [PDF]
, 2011 It is hard to foresee much happiness in the lot of those seeking the original meaning of the Religion Clauses. We may acknowledge the opacity of the historical record, the variety of viewpoints held by founders forgotten and non-forgotten, the ...
Shulman, Jeffrey
core +1 more source
Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway
Molecular Oncology, EarlyView.Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed +10 more
wiley +1 more source
Molecular Oncology, EarlyView.Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra +10 more
wiley +1 more source
Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells
Molecular Oncology, EarlyView.Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son +13 more
wiley +1 more source
The Supreme Court As National School Board [PDF]
, 1949 A modern industrial robot control system is often only based upon measurements from the motors of the manipulator. To perform good tra-ectory tracking on the arm side of the robot a very accurate description of the system must therefore be used.
Karlsson, Rickard, Norrlöf, Mikael
core +1 more source
Molecular Oncology, EarlyView.We developed and validated a DNA methylation–based biomarker panel to distinguish pleural mesothelioma from other pleural conditions. Using the IMPRESS technology, we translated this panel into a clinically applicable assay. The resulting two classifier models demonstrated excellent performance, achieving high AUC values and strong diagnostic accuracy.
Janah Vandenhoeck +12 more
wiley +1 more source
Interseeding Forage Kochia into Established CRP Grass Stands
, 2016 This fact sheet is a summary of a research project that documented that interseeding forage kochia into existing CRP can increase its potential use for fall and winter grazing by livestock.
Banks, Jeffrey E. +2 more
openaire +1 more source
Working Welfare Recipients: A Comparison of the Family Support Act and the Personal Responsibility and Work Opportunity Reconciliation Act [PDF]
, 1997 This Note compares the work requirements of the Family Support Act ( FSA ) with those promulgated by the Personal Responsibility and Work Opportunity Reconciliation Act ( PRWORA ) This Note concludes that the fairest and most effective welfare program ...
Schoen, Lindsay Mara
core +1 more source
Molecular Oncology, EarlyView.We developed a cost‐effective methylation‐specific droplet digital PCR multiplex assay containing tissue‐conserved and tumor‐specific methylation markers. The assay can detect circulating tumor DNA with high accuracy in patients with localized and metastatic colorectal cancer.
Luisa Matos do Canto +8 more
wiley +1 more source
STANDING COMMITTEE ON ETHICS ESTABLISHED BY BOARD [PDF]
Anthropology News, 1969 David F Aberle, David M Schneider
openaire +1 more source