Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang +4 more
wiley +1 more source
The spatial structure evolution of forests in karst areas is a key scientific issue in global forest research. In order to explore the dynamics of spatial structure in karst evergreen and deciduous broad-leaved forests, a study was conducted in Mulun ...
YANG Zhiqi +7 more
doaj +1 more source
A method for generating stand structures using Gibbs marked point process
Stand growth modelling based on single tree responses to their surroundings requires a description of the spatial structure of a stand. While such detailed information is rarely available from field measurements, a method to create it from more general ...
Kokkila, Tero +2 more
doaj +1 more source
Structure‐forward targeting of claudins with synthetic binders
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
Modeling and analysis of horizontal structure of a mixed tree stands (on example of sample plots in the «Bastak» nature reserve in the Middle Amur river area) [PDF]
The results of the research model and real data spatial distribution of trees in single-species, ages and mixed stands are studied. Modeling of the horizontal structure of the stand was based on a computer simulation model.
A. N. Kolobov +2 more
doaj +1 more source
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Basic features of a group selection system modification aimed to sustian regular-uneven-aged stand structure [PDF]
Proposed modification of group selection system is aimed to successfully combine its elements with biological peculiarities (such as sympodial growth, distinct heliotropism and crown growth plasticity, heavy seeds and difficult dissemination, etc.) of ...
Roman Efremov
doaj +2 more sources
Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri +5 more
wiley +1 more source
Quantification of spatial structure of juniper stands in Kandaragh region
This research carried out to quantification of juniper stands structure in Kandragak region. For this purpose, three one-hectare study area were selected and the full calipering and the nearest neighbor’s methods were used to quantification of stand structure.
Kiomars Sefidi +4 more
openaire +1 more source
Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding
In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança +2 more
wiley +1 more source

