Results 81 to 90 of about 8,022,446 (251)
Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
Frontiers in Plant ScienceIntroductionComplex mountain forests in the transition zone between the Qinghai–Tibet and Loess Plateaus are characterized by strong topographic heterogeneity and marked stand structural variation.
Wenzhen Zong +7 more
doaj +1 more source
Ecosphere, 2019 We developed an observational study to (1) examine differences in the structure of mature Douglas‐fir stands representing thinned, structural retention harvest and unmanaged conditions, and (2) assess the extent to which active management in mature ...
Neil Williams, Matthew Powers
doaj +1 more source
Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions
FEBS Letters, EarlyView.The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang +4 more
wiley +1 more source
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Analyzing canopy structure in Pacific Northwest old-growth forests with a stand-scale crown model [PDF]
, 2008 Analyzing canopy structure in Pacific Northwest old-growth forests with a stand-scale crown ...
North, Malcolm, VanPelt, Robert
core +2 more sources
Liver organoids: modelling complexity in homeostasis and disease
FEBS Letters, EarlyView.Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley +1 more source
Quantifying forest stand diversity using stand structure
, 2000 Stand structure is an important component of the overall description of biological diversity in a stand. The diversity of tree sizes within a stand affects tree growth and yield, and is highly correlated with the biodiversity of a stand. Four measures
Staudhammer, Christina Lynn
core +1 more source