Results 81 to 90 of about 940,185 (248)

Adaptor protein CIN85 potentiates the motility of osteosarcoma cells via the Akt/mTOR and MMP2‐COL3A1 axis

Molecular Oncology, EarlyView.
CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak, Iva Staniczková Zambo, Matěj Přikryl, Peter Múdry, Danica Zapletalová, Jarmila Navrátilová, Jiří Navrátil, Jan Šmarda, Liudmyla Drobot, Petr Beneš, Lucia Knopfová   +10 more
wiley   +1 more source

A general class of entropy based control charts

, 2017
We introduce a new class of Shewhart control charts, namely the phi-chart. This new class is based on the cumulative paired phi-divergence that generalizes both the cumulative (residual) entropy and the differential entropy.
Konopik, Jens, Mangold, Benedikt
core  

Revisiting Mission‐Oriented Cancer Research to tackle the increasing burden of cancer in Europe–a policy perspective

Molecular Oncology, EarlyView.
Translational cancer research and its implementation through competitively selected Comprehensive Cancer Centers across Europe should be the primary policy focus for addressing the increasing cancer burden in Europe and counteract the present main strategy to convert cancer to a chronic disease.
Manuel Heitor, Julio Celis, Ulrik Ringborg   +2 more
wiley   +1 more source

Influence of Course Type on Upper Body Muscle Activity in Elite Cross-Country and Downhill Mountain Bikers During Off Road Downhill Cycling [PDF]

, 2012
This study aimed to investigate upper body muscle activity using surface electromyography (sEMG) in elite cross-country (XCO) and downhill (DH) cyclists during off road descending and the influence of man-made (MM) and natural terrain (NT) descents on ...
Atkins, Stephen, Ericsson, Fredrik, Holmberg, Hans-Christer, Hurst, Howard Thomas, Hébert-Losier, Kim, Sinclair, Jonathan Kenneth, Swarén, Mikael   +6 more
core  

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

Molecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata, Koji Ando, Hirofumi Hasuda, Koshi Mimori, Elizabeth C. Unan, Siddhartha Pulukuri, Aahana Tiku, Allison Berger, Eiji Oki, Ajit Bharti, Tomoharu Yoshizumi   +10 more
wiley   +1 more source

On Monitoring of the Shape Parameter of the Inverse Gaussian Distribution via Memoryless Chart Under Bayesian Setup

IEEE Access
The Inverse Gaussian distribution (IGD) is a probability distribution with several applications in various fields. The proposed study is prone to consider the problem of monitoring the shape parameter of IGD using the Bayesian method.
Tahir Abbas, Amara Javed, Nasir Abbas, Muhammad Abid   +3 more
doaj   +1 more source

Metformin promotes mitochondrial integrity through AMPK‐signaling in Leber's hereditary optic neuropathy

FEBS Open Bio, EarlyView.
Metformin mediates mitochondrial quality control in Leber's hereditary optic neuropathy (LHON) fibroblasts carrying mtDNA mutations. At therapeutic levels, metformin activates AMPK signaling to restore mitochondrial dynamics by promoting fusion and restraining fission, while preserving mitochondrial mass, enhancing autophagy/mitophagy and biogenesis ...
Chatnapa Panusatid, Rapasviranda Soiyangsuk, Maneeluck Tanadjindarat, Chayanon Peerapittayamongkol   +3 more
wiley   +1 more source

Late-time growth rate, mixing and anisotropy in the multimode narrowband Richtmyer--Meshkov Instability: the $\theta$-Group Collaboration

, 2017
Turbulent Richtmyer--Meshkov instability (RMI) is investigated through a series of high resolution three dimensional smulations of two initial conditions with eight independent codes.
Attal, N., Batha, C. A., Bigdelou, P., Garside, K. A., Greenough, J., Griffond, J., Kuchugov, P. A., Ladonkina, M. E., Olson, B., Poujade, O., Ramaprabhu, P., Rozanov, V. B., Schilling, O., Thornber, B., Tishkin, V. F., Varshochi, H., Williams, R. J. R., Youngs, D. L., Zhou, Y., Zmitrenko, N. V.   +19 more
core   +1 more source

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

FEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point, Wafaa Achache, Janïs Laudouze, Eliana Sepulveda Ramos, Mickaël Maziero, Céline Crauste, Stéphane Canaan, Pierre Santucci   +7 more
wiley   +1 more source

Exact renormalisation group flow for ultracold Fermi gases in unitary limit

, 2008
We study the exact renormalisation group flow for ultracold Fermi-gases in unitary regime. We introduce a pairing field to describe the formation of the Cooper pairs, and take a simple ansatz for the effective action.
Boris Krippa, Gorkov L P, Krippa B, Krippa B, Krippa B, Litim D F 2002, Schuetz F   +6 more
core   +1 more source