Results 61 to 70 of about 1,177,924 (224)
Low‐density lipoprotein receptor‐related protein 6 (LRP6) is a key receptor for the Wnt antagonist Dickkopf1 (DKK1). DKK1 protein expression is induced in a bleomycin (BLM)‐induced lung injury model. We show that DKK1 induces proinflammatory and profibrotic genes in lung fibroblasts.
Eun‐Ah Sung+6 more
wiley +1 more source
On Non-standard Models of Arithmetic with Uncountable Standard Systems [PDF]
In 1960s, Dana Scott gave a recursion theoretic characterization of standard systems of countable non-standard models of arithmetic, i.e., collections of sets of standard natural numbers coded in non-standard models. Later, Knight and Nadel proved that Scott's characterization also applies to non-standard models of arithmetic with cardinality $\aleph_1$
arxiv
Characteristics of the Kelch domain containing (KLHDC) subfamily and relationships with diseases
The Kelch protein superfamily includes 63 members, with the KLHDC subfamily having 10 proteins. While their functions are not fully understood, recent advances in KLHDC2's structure and role in protein degradation have highlighted its potential for drug development, especially in PROTAC therapies.
Courtney Pilcher+6 more
wiley +1 more source
O Modelo Padrão da Física de Partículas
Inicialmente, apresenta-se, de modo simplificado, o Modelo Padrão como uma teoria sofisticada que identifica as partículas elementares e suas interações.
Marco Antonio Moreira
doaj +1 more source
We present the first solution structure of the Ca2+‐depleted LETM1 F‐EF‐hand through a D676A/N678A Ca2+ binding‐deficient mutant, revealing a closed hydrophobic cleft caused by a unique F1‐helix pivot. The apo LETM1 F‐EF‐hand exhibits regiospecific hot and cold unfolding, sensitivity to physiological pH changes and potential for promiscuous heterotypic
Qi‐Tong Lin+2 more
wiley +1 more source
Status of the Standard Model of Particle Phenomenology [PDF]
The standard model is healthy is all respects except for the non-zero neutrino masses which require an extension of the minimal ...
arxiv
Analysis and improvement of an identity-based signature scheme from lattices
Liu et al proposed an identity-based signature from lattices in 2013,and proved that it can achieve strong un-forgeability in the standard model.Through analysis,the security proof of this scheme has some defect,and then show that the scheme cannot prove
ANGChun-li Y+4 more
doaj
Insertion of the FeB cofactor in cNORs lacking metal inserting chaperones
Nitric oxide reductase is an enzyme found in the bacterial denitrification pathway. The NOR active site contains a non‐heme iron, often, but not always inserted with the assistance of chaperones. Here, we study the insertion of FeB in the subfamily of cNORs lacking chaperones and found a putative channel, conserved in the family, perhaps enabling the ...
Sofia Appelgren, Pia Ädelroth
wiley +1 more source
Quantum Field Theory and the Electroweak Standard Model [PDF]
Lecture notes with a brief introduction to Quantum field theory and the Standard Model are presented. The lectures were given at the 2017 European School of High-Energy Physics. The main features, the present status, and problems of the Standard Model are discussed.
arxiv
LHCPs are transported to the thylakoid membrane via the (cp)SRP pathway. This process involves a transit complex of (cp)SRP43, (cp)SRP54 and LHCP, which interacts with (cp)FtsY and Alb3 at the membrane. GTP hydrolysis by (cp)SRP54 and (cp)FtsY triggers complex dissociation.
Victor Zegarra+7 more
wiley +1 more source