Results 191 to 200 of about 5,314,348 (335)

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Five solar cell parameters automatic extraction, within the one diode-solar cell model, using the implemented Simpson order 5 integration method, in an executable program. [PDF]

PLoS One
Rangel Kuoppa VT.
europepmc   +1 more source

The skills required for transition to university and study in biological sciences: A student perspective

FEBS Open Bio, EarlyView.
Bioscience students were asked for their opinions on the value and teaching of skills. 204 responded that teamwork, time management and study skills are necessary to reach University, that scientific writing, research, laboratory and presentation skills are taught effectively during their studies, while other skills are gained inherently through study ...
Janella Borrell, Susan Crennell
wiley   +1 more source

Audiovisual cues must be predictable and win-paired to drive risky choice. [PDF]

Elife
Hathaway BA, Kim DR, Malhas SBA, Hrelja KM, Kerker L, Hynes TJ, Harris C, Langdon A, Winstanley C.   +8 more
europepmc   +1 more source

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

FEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young, Omar Arias‐Gaguancela, Fiona Gibson, Morgan Grainger, Jodie Score, Amit Nathubhai, Mauricio Cafiero, Lee Richard Machado   +7 more
wiley   +1 more source

Optimizing photoactivation of PA‐mCherry for optical pooled CRISPR screens

FEBS Open Bio, EarlyView.
Photoactivatable PA‐mCherry finds widespread use to optically tag individual cells. However, confocal 405 nm UV laser‐scanning (normal scan) is much less efficient than widefield UV illumination, limiting the use of PA‐mCherry on confocal instruments. We remedy this limitation by reporting that rapid and repeated confocal scanning with a low‐intensity,
Sravasti Mukherjee, Giulia Zanetti, Bram van den Broek, Kees Jalink   +3 more
wiley   +1 more source

Anhedonic Traits Do Not Impair Performance in a 3-Arm Bandit Task. [PDF]

Comput Psychiatr
Ramaswamy A, Yamamori Y, Vivekananda U, Litvak V, Roiser JP.   +4 more
europepmc   +1 more source

Modeling the As-Manufactured Stiffness of Cantilever Beams for First-Time-Right Printing of Compliant Mechanisms with Standard Laser Powder Bed Fusion Process Parameters

Guilain Lang, Julien Rouvinet, Lionel Kiener, Mirko Meboldt   +3 more
openalex   +1 more source

Parameter extraction and optimization for new industry standard VBIC model

, 2002
Xiangyu Cao, John McMacken, K. Stiles, P. Layman, J.J. Liou, Afang Sun, S. Moinian   +6 more
openalex   +2 more sources

On a possibility to calculate fundamental parameters of the Standard\n Model [PDF]

, 2014
B. A. Arbuzov, Ivan Zaitsev
openalex   +1 more source